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  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

1 Tablet(s) Serving Size
60 Servings
Non-Nutrient/Non-Botanical Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

200 mg
📊 Market median: 200.0mg (52 products) 📚 10 studies (Tier A: 0, B: 6)
This product: 200mg

Other Ingredients

Microcrystalline Cellulose Magnesium Silicate Flake Shellac dewaxed Magnesium Stearate Stearic Acid Magnesium Hydroxide Glycerol Silica Arginine Sodium Alginate Calcium Oxide

Label Claims — Verification

All Other
Structure/Function

Target Groups

Vegetarian Adult (18 - 50 Years) Women (not pregnant or lactating) Gluten Free

Product Information

📋 Directions for Use

Suggested Adult Use: Take 1 tablet twice daily between meals, or as recommended by a nutritionally informed physician. Do not chew or crush tablet.

⚠️ Warnings & Precautions

Warning: Individuals using antidepressant medications should consult with their prescribing physician prior to using this product.

Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAM-e.

Do not use if pregnant or nursing.

May cause gastrointestinal discomfort in a small percentage of people.

🧪 Formulation Notes

Helps support mood and neural function Helps support joint comfort and mobility Helps support liver health and detoxification

Vegetarian

Non-GMO Gluten free Soy free

Doctor’s Best SAM-e helps replenish your SAM-e levels and promote a healthy mood. SAM-e (S-Adenosyl-L-Methionine) is naturally produced by your body and helps maintain healthy emotions. Various factors such as diet and aging can cause low levels of SAM-e, leaving you feeling unbalanced and moody. Supplementing with SAM-e Soloesse Italian SAM-e is processed to yield the highest available percentage of the active pure S,S form which helps mediate biochemical activity in the human body.

SAM-e and Mood and Cognitive Function SAM-e helps facilitate DNA enzymatic actions. These enzymatic actions are required for the healthy conversion of neurotransmitters responsible for healthy emotions, such as serotonin and dopamine. SAM-e also facilitates glutathione usage which improves the body’s antioxidant defense and helps maintain acetylcholine levels necessary for cognitive function.

SAM-e and Joint Function In clinical trials, SAM-e has been shown to help increase joint comfort and mobility by promoting the synthesis of proteoglycans, essential components of connective tissue.

SAM-e and Liver Function SAM-e helps support healthy levels of glutathione, a critical antioxidant which helps protect against free radicals. SAM-e acts as a methyl donor in the synthesis and formation of phosphatidylcholine and L-cysteine, both necessary for maintaining liver health.

Doctor's Best utilizes only the highest quality Italian Soloesse SAM-e providing slow and targeted release for improved GI tolerance and absorption. Our SAM-e 200 contains 200 mg of active Soloesse SAM-e in each tablet. This ensures that you receive the most potent SAM-e product with the highest percentage of the active S,S form per serving.

Additional Information

Store in a cool dry place.

SAM-e is sealed in blister packs for freshness and stability.

Product Details

UPC / SKU 7 53950 00206 7
DSLD Entry Date 2022-06-16
Product Type Non-Nutrient/Non-Botanical
Form Tablet or Pill
DSLD ID 269492
Data Updated 2026-04-11

Research Evidence

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