🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

1 Drop(s) Serving Size
250 Servings
Botanical Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

📊 Market median: 983.0mg (16 products) 📚 7 studies (Tier A: 0, B: 1)
This product: 60mg

Label Claims — Verification

All Other
All Other (100% of products) Structure/Function (88% of products) Nutrient (3% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

For aromatic or topical use. Diffuse aromatically or, to apply topically, dilute with a carrier oil to minimize skin sensitivity.

For internal use dilute 1 drop in 4 fl. oz. of liquid.

⚠️ Warnings & Precautions

Caution: Possible skin sensitivity.

Keep out of reach of children.

If pregnant or under a doctor's care, consult your physician.

Avoid contact with eyes, inner ears, and sensitive areas.

🧪 Formulation Notes

Citrus aurantium

Additional Information

CPTG Certified Pure Tested Grade

Product Details

DSLD Entry Date 2022-05-19
Product Type Botanical
Form Liquid
Brand doTERRA
DSLD ID 267565
Data Updated 2026-04-11

Research Evidence

7 Research Sources
51 Avg Quality Score
7 Rct
B p-Synephrine, the main protoalkaloid of Citrus aurantium, raises fat oxidation during exercise in elite cyclists
Rct European journal of sport science 2021
C Effect of p-Synephrine on Fat Oxidation Rate during Exercise of Increasing Intensity in Healthy Active Women
Rct Nutrients 2022
C Does the Time of Day Play a Role in the Acute Effect of p-Synephrine on Fat Oxidation Rate during Exercise in Women? A Randomized, Crossover and Double-Blind Study
Rct Nutrients 2022
C Effects of p-synephrine alone and in combination with selected bioflavonoids on resting metabolism, blood pressure, heart rate and self-reported mood changes
Rct International journal of medical sciences 2011
C Acute p-synephrine ingestion increases whole-body fat oxidation during 1-h of cycling at Fatmax
Rct European journal of nutrition 2020
C Acute p-synephrine ingestion increases fat oxidation rate during exercise
Rct British journal of clinical pharmacology 2016
C Dose-Response Effects of p-Synephrine on Fat Oxidation Rate During Exercise of Increasing Intensity
Rct Phytotherapy research : PTR 2018
View all evidence for Bitter Orange →

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