OptiFlex + by DC — Ingredients, Evidence & Safety

Product Label

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Label Data

2 Tablet(s) Serving Size

30 Servings

Other Combinations Product Type

100% Evidence Coverage

Supplement Facts — Evidence Check

Glucosamine Hydrochloride

1000 mg

📊 Market median: 1000.0mg (1115 products) 📚 22 studies (Tier A: 0, B: 9)

This product: 1000mg

Chondroitin Sulfate

800 mg

📊 Market median: 600.0mg (79 products) 📚 24 studies (Tier A: 0, B: 6)

This product: 800mg

Hydrolyzed Collagen 1&3

100 mg

📊 Market median: 20.0mg (931 products) 📚 233 studies (Tier A: 1, B: 90)

This product: 100mg

Other Ingredients

Cellulose Stearic Acid Silica

Label Claims — Verification

❓ Nutrient

❓ All Other

❓ Structure/Function

All Other (100% of products) Structure/Function (89% of products) Nutrient (16% of products)

Target Groups

Adult (18 - 50 Years) Women (not pregnant or lactating) Gluten Free

Product Information

📋 Directions for Use

Directions: As a dietary supplement, take two tablets twice daily with a meal.

⚠️ Warnings & Precautions

Tamper Evident: Do not use this product if imprinted foil seal under cap is broken or missing.

Keep out of reach of children.

Caution: Do not take this product if you are pregnant, nursing or allergic to shell fish.

Contains crustacean shellfish (crab & shrimp) ingredients.

🧪 Formulation Notes

This nutritional combination of ingredients helps maintain healthy joints and cartilage.

Mfg. in an FDA Registered Facility using Good Manufacturing Practices (GMPs)

Conforms to USP <2091> for weight. Meets USP <2040> disintegration for maximum bioavailability.

Now with collagen

Gluten free

Glucosamine HCI Chondroitin sulfate Hydrolyzed collagen

Helps maintain healthy joint and cartilage

PureFlex

Made in USA

Additional Information

Keep tightly closed. Store at room temperature: 59 degrees - 86 degrees F (15 degrees to 30 degrees C).

Quali Pure

Product Details

DSLD Entry Date 2022-06-16

Product Type Other Combinations

Form Tablet or Pill

Brand DC

DSLD ID 267007

Data Updated 2026-04-11

Research Evidence

39 Research Sources

50 Avg Quality Score

20 Rct

9 Meta Analysis

4 Clinical Trial

3 Systematic Review

1 Regulatory Source

1 Openfda Safety

B Interventions for the management of temporomandibular joint osteoarthritis

Systematic Review The Cochrane database of systematic reviews 2012

PubMed DOI Cochrane

B Glucosamine therapy for treating osteoarthritis

Meta Analysis The Cochrane database of systematic reviews 2005

PubMed Cochrane

B Chondroitin for osteoarthritis

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI Cochrane

B Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis

Meta Analysis Archives of orthopaedic and trauma surgery 2023

PubMed DOI

B Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis

Rct The New England journal of medicine 2006

PubMed

B Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review

Systematic Review International journal of molecular sciences 2023

PubMed DOI

B Scientific Opinion on glucosamine and joint health

Regulatory Source EFSA Journal 2009

DOI

B Clinical Efficacy and Safety of Chondroitin Combined with Glucosamine in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis

Meta Analysis Computational and mathematical methods in medicine 2022

PubMed DOI

B Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib

Rct Annals of the rheumatic diseases 2016

PubMed DOI

B Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials

Meta Analysis Journal of orthopaedic surgery and research 2018

PubMed DOI

View all evidence for Glucosamine →