Home/ Supplements/ Berberine/ Berberine 1000 mg

Berberine 1000 mg

product on market Capsule aSquared Nutrition Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Berberine HCl is supported by strong evidence for its role in improving glycemic control and lipid metabolism. Research indicates it may help lower blood glucose levels by activating AMP-K. The current evidence base for these metabolic effects is considered robust across multiple clinical studies.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Berberine 1000 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Vegetable Capsule(s)
Serving Size
90
Servings
Non-Nutrient/Non-Botanical
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

1000 mg
Market median: 500.0mg (234 products) 95 studies (A:0, B:35)

Other Ingredients

Vegetable Cellulose Rice Flour
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use: Take two (2) capsules once a day, preferably with meals or as directed by your healthcare professional.

Warnings & Precautions

Caution: Do not exceed the recommended dose.

This product is not intended for pregnant or nursing mothers or children under the age of 18.

This product is not intended for pregnant or nursing mothers or children under the age of 18.

As always, consult your physician before using this or any dietary supplement.

If you are taking any other medications, consult your doctor before using this product.

Discontinue use of this product and consult your doctor if any adverse reactions occur.

GMP Good Manufacturing Practice Quality Assured

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Formulation Notes

Vegan friendly

Natural formulation Helps support cardiovascular health Promotes a healthy immune system Helps maintain healthy cholesterol levels

Berberine is a natural alkaloid found in several herbs and plants including European barberry, Oregon grape, and tree turmeric. For generations, Berberine has shown to help support overall cardiovascular and immune system health.

Additional Information

Please recycle

Store in a cool, dry place.

180 capsules

USA Formulated

Metadata

Product Details

UPC / SKUX000XUD1JF
DSLD Entry Date2022-05-19
Product TypeNon-Nutrient/Non-Botanical
FormCapsule
BrandaSquared Nutrition
DSLD ID263851
Data Updated2026-04-11
Research

Research Evidence

98
Research Sources
55
Avg Quality
48
Systematic Review
39
Meta Analysis
4
Rct
4
Clinical Trial
1
Other
1
Narrative Review
1
Openfda Safety
B Efficacy and safety of berberine for dyslipidaemias: A systematic review and meta-analysis of randomized clinical trials
Meta Analysis Phytomedicine : international journal of phytotherapy and phytopharmacology 2018 PubMed DOI
B Effects berberine-silymarin on liver enzymes: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition ESPEN 2022 PubMed DOI
B Efficacy and safety of berberine for several cardiovascular diseases: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 PubMed DOI
B Effect of Berberine on C-reactive protein: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2019 PubMed DOI
B Overall and Sex-Specific Effect of Berberine on Glycemic and Insulin-Related Traits: a Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis The Journal of nutrition 2023 PubMed DOI
B The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review
Meta Analysis Journal of translational medicine 2024 PubMed DOI
B Berberine Effects in Pre-Fibrotic Stages of Non-Alcoholic Fatty Liver Disease-Clinical and Pre-Clinical Overview and Systematic Review of the Literature
Systematic Review International journal of molecular sciences 2024 PubMed DOI
B Efficacy and Safety of Berberine Alone or Combined with Statins for the Treatment of Hyperlipidemia: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials
Meta Analysis The American journal of Chinese medicine 2019 PubMed DOI
B Effects of Berries, Phytochemicals, and Probiotics on Atherosclerosis through Gut Microbiota Modification: A Meta-Analysis of Animal Studies
Meta Analysis International journal of molecular sciences 2023 PubMed DOI
B Berberine Ursodeoxycholate for the Treatment of Type 2 Diabetes: A Randomized Clinical Trial
Rct JAMA network open 2025 PubMed DOI
View all evidence for Berberine →
Compare

Similar Products

WellBetX Berberine 500 mg
Natural Factors · Capsule
100
Advanced Berberine 1200
Bio Nutrition · Capsule
100
Goldenseal Extract 100 mg
Spring Valley · Capsule
100
WellBetX Berberine 500 mg
Natural Factors · Capsule
100
Berberine 500 mg
Botanic Choice · Capsule
100
View all Berberine products →
Berberine research Best Berberine All Berberine products More from aSquared Nutrition View on NIH DSLD →

This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.