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Glucosamine Hydrochloride 500 mg

product on market Capsule Wonder Laboratories Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Glucosamine hydrochloride is used to support joint health and cartilage maintenance. Research provides moderate evidence that it may help reduce joint pain and stiffness associated with osteoarthritis. The ingredient is generally well-tolerated with a high safety profile.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Glucosamine Hydrochloride 500 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
100
Servings
Non-Nutrient/Non-Botanical
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 1000.0mg (1115 products) 24 studies (A:0, B:9)

Other Ingredients

Gelatin Vegetable Cellulose Vegetable Magnesium Stearate Silica
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: As a dietary supplement, take 1 capsule three times daily.

Warnings & Precautions

Tamper Evident: Do not use this product if imprinted foil seal under cap is broken or missing.

Keep out of reach of children.

Caution: Do not take this product if you are pregnant nursing, or allergic to shell fish.

Caution: Do not take this product if you are pregnant nursing, or allergic to shell fish.

Contains crustacean shellfish (crab & shrimp) ingredients.

Formulation Notes

Glucosamine HCL is the most versatile and bioavailable amino sugar that the body converts into essential biomolecules. Glucosamine is often called "cellular glue". It is the main building block for semi-fluids that lubricate joints and fill their cushioning sacks (bursa). It also forms the core of skeletal bone of cell recognition molecules.

Mfg. in a FDA registered facility using Good Manufacturing Practices (GMPs)

Helps maintain healthy joints and cartilage.

Contains crustacean shellfish (crab & shrimp) ingredients.

Conforms to USP <2091> for weight. Meets USP <2040> disintegration for maximum bioavailability.

Made in USA

Additional Information

Keep tightly closed Store at room temperature: 59 degrees-86 degrees F (15 degrees to 30 degrees C).

Formula 582

Metadata

Product Details

DSLD Entry Date2021-11-19
Product TypeNon-Nutrient/Non-Botanical
FormCapsule
BrandWonder Laboratories
DSLD ID260797
Data Updated2026-04-11
Research

Research Evidence

39
Research Sources
50
Avg Quality
20
Rct
9
Meta Analysis
4
Clinical Trial
3
Systematic Review
1
Regulatory Source
1
Openfda Safety
B Interventions for the management of temporomandibular joint osteoarthritis
Systematic Review The Cochrane database of systematic reviews 2012 PubMed DOI
B Glucosamine therapy for treating osteoarthritis
Meta Analysis The Cochrane database of systematic reviews 2005 PubMed
B Chondroitin for osteoarthritis
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis
Meta Analysis Archives of orthopaedic and trauma surgery 2023 PubMed DOI
B Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis
Rct The New England journal of medicine 2006 PubMed
B Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review
Systematic Review International journal of molecular sciences 2023 PubMed DOI
B Scientific Opinion on glucosamine and joint health
Regulatory Source EFSA Journal 2009 DOI
B Clinical Efficacy and Safety of Chondroitin Combined with Glucosamine in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis
Meta Analysis Computational and mathematical methods in medicine 2022 PubMed DOI
B Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib
Rct Annals of the rheumatic diseases 2016 PubMed DOI
B Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials
Meta Analysis Journal of orthopaedic surgery and research 2018 PubMed DOI
View all evidence for Glucosamine →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.