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Methyl B-12 2500 mcg

product on market Other (e.g. tea bag) GNC Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 50% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Vitamin B12 is supported by strong evidence for maintaining nerve function and supporting red blood cell formation. Calcium is well-documented for its role in bone health and muscle contraction. These ingredients are generally recognized as safe for supplementation within recommended daily limits.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Methyl B-12 2500 mcg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Caplet(s)
Serving Size
100
Servings
Single Vitamin and Mineral
Product Type
50%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

2500 mcg (104167% DV)
1041.7× RDA — above typical dose 139 studies (A:1, B:44)
Calcium
135 mg (10% DV)

Other Ingredients

Dicalcium Phosphate Microcrystalline Cellulose Hydroxypropyl Methylcellulose Silicon Dioxide Stearic Acid Titanium Dioxide Magnesium Stearate Croscarmellose Sodium Polyethylene Glycol Talc Carnauba wax
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: As a dietary supplement, take one caplet daily.

Warnings & Precautions

Keep out of reach of children.

Formulation Notes

Highly absorbable Essential for carbohydrate metabolism & energy production Required for red blood cell formation

High potency Methyl B-12

No artificial flavors, gluten free, no milk. Gf gluten free

Additional Information

For more information: 1-888-462-2548 GNC.com

100-day supply

Store in a cool, dry place.

Metadata

Product Details

UPC / SKU0 48107 20574 4
DSLD Entry Date2022-02-23
Product TypeSingle Vitamin and Mineral
FormOther (e.g. tea bag)
BrandGNC
DSLD ID260268
Data Updated2026-04-11
Research

Research Evidence

237
Research Sources
53
Avg Quality
83
Meta Analysis
74
Systematic Review
45
Rct
29
Clinical Trial
2
Guideline
2
Regulatory Source
1
Openfda Safety
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
A Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression
Meta Analysis Nutrients 2021 PubMed DOI
A Efficacy of different routes of vitamin B12 supplementation for the treatment of patients with vitamin B12 deficiency: A systematic review and network meta-analysis
Systematic Review Irish journal of medical science 2024 PubMed DOI
B Helicobacter pylori infection and micronutrient deficiency in pregnant women: a systematic review and meta-analysis
Meta Analysis BMJ open gastroenterology 2020 PubMed DOI
B Vitamin B12 supplementation during pregnancy for maternal and child health outcomes
Systematic Review The Cochrane database of systematic reviews 2024 PubMed DOI
B A comprehensive review and meta-regression analysis of randomized controlled trials examining the impact of vitamin B12 supplementation on homocysteine levels
Meta Analysis Nutrition reviews 2024 PubMed DOI
B Relationship between vitamin B12 levels and motor development: A systematic review
Systematic Review Clinical nutrition ESPEN 2024 PubMed DOI
B Vitamin B12, folate, and homocysteine in metabolic syndrome: a systematic review and meta-analysis
Meta Analysis Frontiers in endocrinology 2023 PubMed DOI
View all evidence for Vitamin B12 →
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Vitamin B12 research Best Vitamin B12 All Vitamin B12 products More from GNC View on NIH DSLD →

This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.