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MSM with GS-500

product on market Capsule Nature's Way Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 50% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Methylsulfonylmethane and glucosamine sulfate are commonly used to support joint health and cartilage maintenance. Research providing evidence for these ingredients is generally moderate, though individual results vary. The profile includes sodium and chloride, which serve as stabilizing components in the sulfate formulation.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for MSM with GS-500
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
180
Servings
Other Combinations
Product Type
50%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

77 mg (2% DV)
Market median: 4002.0mg (1 products) 21 studies (A:0, B:2)
Sodium
50 mg (2% DV)
Market median: 1000.0mg (1115 products) 24 studies (A:0, B:9)
Market median: 1000.0mg (2 products)

Other Ingredients

Hypromellose Magnesium Stearate Silica
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Recommendation: Take 1 capsule up to three times daily.

Warnings & Precautions

Keep out of reach of children.

Safety sealed with printed inner seal. Do not use if seal is broken or missing.

If you are pregnant, nursing or taking any medications, consult a healthcare professional before use.

Contains shellfish (shrimp and crab).

Formulation Notes

Pure OptiMSM with stabilized glucosamine sulfate

Glucosamine is a precursor of glycosaminoglycans, a component of cartilage

Gluten free. No yeast-derived ingredients, wheat, soy, dairy products, or artificial colors, flavors or preservatives.

OptiMSM

Helps support healthy joints

Additional Information

Helps support healthy joints and cartilage

Quality Global Sourcing - Bottled & Tested in the USA

Value size

Metadata

Product Details

UPC / SKU7 63948 07550 8
DSLD Entry Date2022-01-22
Product TypeOther Combinations
FormCapsule
BrandNature's Way
DSLD ID259471
Data Updated2026-04-11
Research

Research Evidence

849
Research Sources
56
Avg Quality
450
Meta Analysis
152
Rct
137
Systematic Review
73
Clinical Trial
11
Regulatory Source
7
Other
7
Guideline
3
Openfda Safety
2
Cochrane Review
2
Observational
A Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD)
Meta Analysis The Cochrane database of systematic reviews 2018 PubMed DOI
A Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes
Meta Analysis The Cochrane database of systematic reviews 2024 PubMed DOI
A Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life
Meta Analysis The Cochrane database of systematic reviews 2018 PubMed DOI
A Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
A Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps
Systematic Review The Cochrane database of systematic reviews 2008 PubMed DOI
A Calcium and vitamin D for increasing bone mineral density in premenopausal women
Systematic Review The Cochrane database of systematic reviews 2023 PubMed DOI
A Dietary sodium, sodium-to-potassium ratio, and risk of stroke: A systematic review and nonlinear dose-response meta-analysis
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2019 PubMed DOI
A The association between circulating magnesium and clinically relevant outcomes in patients with chronic kidney disease: A systematic review and meta-analysis
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2021 PubMed DOI
A Calcium channel blockers versus other classes of drugs for hypertension
Systematic Review The Cochrane database of systematic reviews 2021 PubMed DOI
View all evidence for Electrolytes →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.