Home/ Supplements/ Berberine/ Berberine Extract 500 mg

Berberine Extract 500 mg

product on market Capsule Natural Grocers by Vitamin Cottage Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Berberine sulfate is supported by moderate to strong evidence for helping manage blood glucose levels and lipid profiles. Research indicates it may improve insulin sensitivity and metabolic health. However, overall evidence coverage for this specific formulation remains limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Berberine Extract 500 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Vegetarian Capsule(s)
Serving Size
30
Servings
Non-Nutrient/Non-Botanical
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 500.0mg (234 products) 95 studies (A:0, B:35)

Other Ingredients

Microcrystalline Cellulose Capsule Magnesium Stearate Silica Rice Bran
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested use: As a dietary supplement, adults take two (2) vegetarian capsule daily, or as directed by a health care professional.

Warnings & Precautions

Caution: As with any supplement, consult your healthcare practitioner before using this product, especially if you are pregnant, nursing, or are under medical supervision for any reason.

Keep out of reach of children.

For serious adverse event reporting call (877) 455-2826.

Formulation Notes

We only put our name on formulas that meet our unrivaled quality standards, and we continue raising the bar on these standards without raising the bar on your budget. Our supplements are GMP (Good Manufacturing Practices) certified, ingredient verified, screened for heavy metals, and formulated without questionable fillers, artificial colors, sweeteners, flavors, and other problematic ingredients. We scrutinize every detail, so you don't have to, because we are, and always have been, your Original good4u Grocers. To your health, - The Isely Family

Our supplements are GMP (Good Manufacturing Practices) certified, ingredient verified, screened for heavy metals, and formulated without questionable fillers, artificial colors, sweeteners, flavors, and other problematic ingredients.

Glucose support

GF (Gluten free)

Vegetarian

Contains no: Sugar, salt, dairy, yeast, wheat, gluten, corn, soy, preservatives, artificial colors or flavors.

Berberine Extract 500 mg per 2 caps

Additional Information

Store in a cool, dry place and away from direct light.

GMP Good Manufacturing Practice

Made in USA

BPA Free

Metadata

Product Details

UPC / SKU8 49327 00290 4
DSLD Entry Date2021-11-19
Product TypeNon-Nutrient/Non-Botanical
FormCapsule
DSLD ID256840
Data Updated2026-04-11
Research

Research Evidence

98
Research Sources
55
Avg Quality
48
Systematic Review
39
Meta Analysis
4
Rct
4
Clinical Trial
1
Other
1
Narrative Review
1
Openfda Safety
B Efficacy and safety of berberine for dyslipidaemias: A systematic review and meta-analysis of randomized clinical trials
Meta Analysis Phytomedicine : international journal of phytotherapy and phytopharmacology 2018 PubMed DOI
B Effects berberine-silymarin on liver enzymes: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition ESPEN 2022 PubMed DOI
B Efficacy and safety of berberine for several cardiovascular diseases: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 PubMed DOI
B Effect of Berberine on C-reactive protein: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2019 PubMed DOI
B Overall and Sex-Specific Effect of Berberine on Glycemic and Insulin-Related Traits: a Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis The Journal of nutrition 2023 PubMed DOI
B The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review
Meta Analysis Journal of translational medicine 2024 PubMed DOI
B Berberine Effects in Pre-Fibrotic Stages of Non-Alcoholic Fatty Liver Disease-Clinical and Pre-Clinical Overview and Systematic Review of the Literature
Systematic Review International journal of molecular sciences 2024 PubMed DOI
B Efficacy and Safety of Berberine Alone or Combined with Statins for the Treatment of Hyperlipidemia: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials
Meta Analysis The American journal of Chinese medicine 2019 PubMed DOI
B Effects of Berries, Phytochemicals, and Probiotics on Atherosclerosis through Gut Microbiota Modification: A Meta-Analysis of Animal Studies
Meta Analysis International journal of molecular sciences 2023 PubMed DOI
B Berberine Ursodeoxycholate for the Treatment of Type 2 Diabetes: A Randomized Clinical Trial
Rct JAMA network open 2025 PubMed DOI
View all evidence for Berberine →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.