5-HTP

product on market Capsule Vera's Formulations Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

L-5-Hydroxytryptophan is a precursor to serotonin with moderate evidence supporting its use for mood and sleep. Pyridoxal 5-Phosphate serves as a coenzyme in the synthesis of neurotransmitters. Overall evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for 5-HTP
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
30
Servings
Other Combinations
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 100.0mg (116 products) 18 studies (A:0, B:3)
4.1× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Adult Dose: Take 1 capsule per day on an empty stomach with juice or water, or as recommended by your registered healthcare practitioner.

Warnings & Precautions

For Practitioner Dispensing Only

Warnings: If symptoms persist consult your healthcare practitioner.

Avoid during pregnancy and lactation.

Vitamin supplements should not replace a balanced diet. Do not use if tamper evidence seal is broken. Bottle sealed under cap for your protection.

Keep out of reach of children.

Formulation Notes

Indications: Supports healthy mood balance and sleep.

Sleep and mood support

Vegan Friendly.

Additional Information

Store below 30 degrees C in a cool, dry place away from direct sunlight. Refrigerate after opening.

Proudly Australian Owned

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Metadata

Product Details

UPC / SKU9 319091 412717
DSLD Entry Date2021-08-23
Product TypeOther Combinations
FormCapsule
DSLD ID256590
Data Updated2026-04-11
Research

Research Evidence

21
Research Sources
53
Avg Quality
11
Systematic Review
6
Rct
4
Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025 PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023 PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025 PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010 PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020 PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025 PubMed DOI
View all evidence for 5 Htp →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.