5-HTP

product on market Capsule WholeHealth Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

5-Hydroxytryptophan serves as a precursor to serotonin and is researched for its role in supporting mood regulation. There is moderate evidence suggesting its efficacy in managing certain depressive symptoms. However, overall evidence coverage for this specific profile remains limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for 5-HTP
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
60
Servings
Amino acid/Protein
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 100.0mg (116 products) 18 studies (A:0, B:3)

Other Ingredients

Microcrystalline Cellulose Vegetable capsule
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use: As a dietary supplement, adults take one to three capsules daily with water, or as recommended by a health care practitioner.

Warnings & Precautions

Warning: Not for use by persons under 18 or by pregnant or lactating women. Consult your health care practitioners prior to use and inform your pharmacist of all dietary supplements you are taking.

Warning: Not for use by persons under 18 or by pregnant or lactating women. Consult your health care practitioners prior to use and inform your pharmacist of all dietary supplements you are taking.

Keep out of reach of children.

Do not use if outer seal is broken or missing.

May cause drowsiness. Do not drive, operate machinery or consume alcohol when taking this product.

Formulation Notes

Wholehealth premium supplements

5-Hydroxytryptophan Peak x free

Does not contain: milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, or soybeans.

Vegetarian product

Made in the U.S.A using the highest quality ingredients carefully sourced from around the world. Lab-assayed for purity.

Additional Information

The trusted name in natural health products

Store tightly closed in a cool, dry place.

Metadata

Product Details

UPC / SKU8 36485 00117 7
DSLD Entry Date2021-07-27
Product TypeAmino acid/Protein
FormCapsule
DSLD ID248354
Data Updated2026-04-11
Research

Research Evidence

21
Research Sources
53
Avg Quality
11
Systematic Review
6
Rct
4
Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025 PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023 PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025 PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010 PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020 PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025 PubMed DOI
View all evidence for 5 Htp →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.