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BioCoenzymated Benfotiamine 150 mg plus Sulbutiamine

product on market Capsule Natural Factors Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 67% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

Benfotiamine and sulbutiamine are lipid-soluble derivatives of thiamine that cross cell membranes more effectively than standard thiamine. Moderate evidence suggests these compounds support glucose metabolism and neurological function. Research indicates they are generally well-tolerated with a high safety profile.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for BioCoenzymated Benfotiamine 150 mg plus Sulbutiamine
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Vegetarian Capsule(s)
Serving Size
Other Combinations
Product Type
67%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

110 mg (9192% DV)
91.7× RDA — above typical dose 76 studies (A:0, B:33)
150 mg
125.0× RDA — above typical dose 76 studies (A:0, B:33)
Sulbutiamine
13.5 mg

Other Ingredients

Microcrystalline Cellulose Vegetarian Capsule Farm Fresh Factors Magnesium Stearate Stearic Acid
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested usage: 1 capsule 1-3 times per day or as directed by a health professional.

Warnings & Precautions

Cautions: As with any supplement, consult your health professional before use if you are pregnant, breastfeeding, or trying to conceive, or if you are taking medication, have a medical condition, or anticipate surgery.

Keep out of the reach of children.

Sealed for your protection. Do not use if seal is broken.

Formulation Notes

Thiamin (vitamin B1) is a water soluble vitamin that supports glucose metabolism and normal growth and development.

Natural Factors BioCoenzymated formula contains a specialized combination of benfotiamine and thiamine diphosphate which are coenzyme forms of vitamin B1.

Taking benfotiamine and sulbutiamine allows for greater absorption and biovailability than non-coenzyme forms. Benfotiamine is fat soluble which allows it to cross cell membranes. Furthermore, it stimulates transketolase, the enzyme essential for maintaining normal glucose metabolic pathways. It also supports healthy nervous system function and helps protect the body's tissues against advanced glycation end products (AGEs).

Natural Factors BioCoenzymated Benfotiamine with thiamine diphosphate is truly the next generation B1!

Manufactured by Natural Factors to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.

Contains no artificial colors, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs.

Suitable for vegetarians/vegans.

B1 The most metabolically active form

isura This product has passed the most rigorous testing in the world for contaminants and quality. isura.ca

What does coenzymated mean? In order for B vitamins to be utilized effectively by they body, they must be converted into their metabolically active coenzyme forms. For example, two coenzyme forms of thiamin are benfotiamine and thiamine diphosphate. A coenzyme is a naturally occurring compound that partners with specific enzymes in order to help promote a number of beneficial metabolic reactions in the body. Without the coenzyme, the enzyme cannot promote the biochemical reaction that is responsible for our survival. The dual cooperation between coenzyme and enzyme is a process called coenzymated. Taking B vitamins already in their coenzymated forms allows the body to use them directly. Thus, the amount that is needed by the body is less in order to achieve the same benefits. Biocoenzymated takes it one step further. Using our proprietary EnviroSimplex technology, we've created a unique biocoenzymated process using organic, farm fresh plant extracts from whole food sources and the coenzyme form of B vitamins. The synergy between the phytochemicals found in these plant extracts and the coenzyme B vitamin optimizes absorption. The results? Biocoenzymated delivers the most metabolically active nutrients to your cells to utilize most effectively. Feel the difference.

Additional Information

isura Non-GMO - Mass Spec Documentation Lab tested

For freshness, store in a cool, dry place.

Product of Canada Recyclable container and label.

Purity & Potency Guaranteed

Metadata

Product Details

UPC / SKU0 68958 01248 3
DSLD Entry Date2021-04-22
Product TypeOther Combinations
FormCapsule
DSLD ID247472
Data Updated2026-04-11
Research

Research Evidence

100
Research Sources
56
Avg Quality
48
Systematic Review
30
Meta Analysis
13
Rct
6
Clinical Trial
1
Cochrane Review
1
Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013 PubMed DOI
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023 PubMed DOI
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022 PubMed DOI
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022 PubMed DOI
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020 PubMed DOI
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021 PubMed DOI
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022 PubMed DOI
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023 PubMed DOI
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004 PubMed
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.