E-400

product on market Softgel Capsule Douglas Cooper Co. Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Vitamin E acts as a potent antioxidant that helps protect cells from oxidative stress. There is strong evidence supporting its role in maintaining immune function and skin health. However, the overall evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for E-400
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Softgel(s)
Serving Size
100
Servings
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

400 IU (1333% DV)
17.9× RDA — above typical dose (UL: 1000 mg) 179 studies (A:3, B:90)

Other Ingredients

Softgel Capsule organic extra virgin Olive Oil
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Qualified Health
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Usage: Take 1 softgel daily with a meal.

Warnings & Precautions

Caution: For adults only.

Consult a physician if pregnant/nursing, taking medication, or have a medical condition.

Keep out of reach of children.

Do not eat freshness packet. Keep in bottle.

To report a serious adverse event, or for product information, contact 1-800-234-8686

Contains soy (non-GMO).

Not manufactured with yeast, wheat, gluten, milk, egg, fish or shellfish ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Formulation Notes

Vitamin E is a major antioxidant and the primary defense against lipid peroxidation. It is particularly important in protecting the body's cells from free radical/oxidative damage. Cell protection against oxidative damage is achievable with supplemental intakes higher than what is normally consumed in the average diet.

Some scientific evidence suggests that consumption of antioxidant vitamins may reduce the risk of certain forms of cancer. However FDA has determined that this evidence is limited and not conclusive.

Natural color variation may occur in this product.

100% Natural

Mixed tocopherols

Not manufactured with yeast, wheat, gluten, milk, egg, fish or shellfish ingredients.

Non-GMO

Additional Information

Douglas Cooper Co. "Trace Minerals Make the Difference" Since 1950

Store in a cool, dry place after opening.

Please recycle.

Metadata

Product Details

DSLD Entry Date2021-05-22
Product TypeVitamin
FormSoftgel Capsule
DSLD ID247297
Data Updated2026-04-11
Research

Research Evidence

253
Research Sources
55
Avg Quality
128
Meta Analysis
52
Systematic Review
41
Rct
24
Clinical Trial
3
Regulatory Source
1
Narrative Review
1
Other
1
Guideline
1
Openfda Safety
A Vitamin E supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Vitamin E for Alzheimer's dementia and mild cognitive impairment
Systematic Review The Cochrane database of systematic reviews 2017 PubMed DOI
A Vitamin E for Alzheimer's disease and mild cognitive impairment
Meta Analysis The Cochrane database of systematic reviews 2008 PubMed DOI
A Vitamin E for Alzheimer's dementia and mild cognitive impairment
Meta Analysis The Cochrane database of systematic reviews 2012 PubMed DOI
A Exercise for intermittent claudication
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Effects of vitamin E supplementation on the risk and progression of AD: a systematic review and meta-analysis
Meta Analysis Nutritional neuroscience 2021 PubMed DOI
A Effect of vitamin E supplementation in rheumatoid arthritis: a systematic review and meta-analysis
Meta Analysis European journal of clinical nutrition 2023 PubMed DOI
A Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
Rct JAMA 2011 PubMed DOI
A Vitamin E for Alzheimer's dementia and mild cognitive impairment
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
B Vitamin, Mineral, and Multivitamin Supplementation to Prevent Cardiovascular Disease and Cancer: US Preventive Services Task Force Recommendation Statement.
Guideline JAMA 2022 PubMed DOI
View all evidence for Vitamin E →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.