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5-HTP

product on market Capsule Metabolic Maintenance Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 50% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

5-HTP is used to support serotonin levels, while vitamins B6 and C act as cofactors in neurotransmitter synthesis. Glycine serves as an inhibitory neurotransmitter to support relaxation. Research evidence for this specific combination is limited, though individual ingredients have moderate to strong clinical support.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for 5-HTP
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
Other Combinations
Product Type
50%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Vitamin C
150 mg (250% DV)
3 mg (150% DV)
2.3× RDA — within safe limits 114 studies (A:3, B:35)
100 mg
Market median: 100.0mg (116 products) 18 studies (A:0, B:3)
Glycine
440 mg

Other Ingredients

vegetarian capsule
Claims

Label Claims — Verification

Unverified All Other
Info

Product Information

Directions for Use

DIRECTIONS: One (1) capsule daily as a dietary supplement, or as directed by a Doctor. Best taken between meals or at bedtime.

Warnings & Precautions

KEEP OUT OF THE REACH OF CHILDREN.

CAUTION: Do not take with MAO inhibitors or tricyclic antidepressants.

Pregnant or lactating women, consult your healthcare professional before taking this product.

Formulation Notes

Each preservative-free vegetarian capsule contains only the active ingredients listed on the label.

Excipient-free.

Additional Information

STORAGE: Keep tightly closed in a dry place; do not expose to excessive heat.

#22826A EXP 3/13

Manufactured in a GMP Certified Facility

V.07

Metadata

Product Details

UPC / SKU8 38287 00101 0
DSLD Entry Date2013-08-23
Product TypeOther Combinations
FormCapsule
BrandMetabolic Maintenance
DSLD ID24705
Data Updated2026-04-11
Research

Research Evidence

21
Research Sources
53
Avg Quality
11
Systematic Review
6
Rct
4
Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025 PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023 PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025 PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010 PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020 PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025 PubMed DOI
View all evidence for 5 Htp →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.