5-HTP

product on market Capsule We Like Vitamins Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

5-Hydroxytryptophan is a precursor to serotonin used in research to support mood and sleep regulation. There is moderate evidence suggesting its efficacy for managing depressive symptoms. However, overall evidence coverage for this specific formulation remains limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for 5-HTP
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
180
Servings
Amino acid/Protein
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 100.0mg (116 products) 18 studies (A:0, B:3)

Other Ingredients

Gelatin Rice powder
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested use: For adults, take one (1) capsule daily, preferably with a meal or as directed by a healthcare professional. As a reminder, always discuss all supplements with your health care provider.

Warnings & Precautions

Warning: Not for use by pregnant or lactating women. Do not use with antidepressants or weight control drugs.

May cause drowsiness: Do not drive a motor vehicle or operate heavy machinery or equipment while using this product. Do not exceed recommended dose.

Consult a doctor before use if you have, or have had, any health condition or are taking any medications or OTC medication, or are planning any medical procedure.

Stop use if any adverse reactions occur.

Keep out of reach of children.

Not for use by persons under 18 years of age.

Formulation Notes

5-HTP 100 mg

Helps to support sleep & appetite Helps to support stress levels & mood

Zero: preservatives, artificial colors, artificial flavors, yeast, corn, milk or milk derivatives, lactose, salt, sodium, soy, sugar, gluten, starch, or wheat.

Additional Information

Store in a cool, dry place. Avoid excessive heat or moisture.

Vitamin angels proud supporter Every bottle counts every time you purchase from us helps to provide life-changing vitamins to a mother or child in need. Thank you!

Metadata

Product Details

DSLD Entry Date2021-02-25
Product TypeAmino acid/Protein
FormCapsule
DSLD ID244104
Data Updated2026-04-11
Research

Research Evidence

21
Research Sources
53
Avg Quality
11
Systematic Review
6
Rct
4
Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025 PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023 PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025 PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010 PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020 PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025 PubMed DOI
View all evidence for 5 Htp →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.