🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 67% of ingredients have research evidence
A Label Compliance Grade

Product Label

📸

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Label Data

1 Tablet(s) Serving Size
Other Combinations Product Type
67% Evidence Coverage

Supplement Facts — Evidence Check

10 mcg (50% DV)
✅ Within RDA (0.7× RDA of 0.015 mg) 📚 604 studies (Tier A: 16, B: 251)
RDA 0.015mg This product: 0.01mg UL 0.1mg
📊 Market median: 375.0mg (171 products) 📚 30 studies (Tier A: 1, B: 14)
This product: 100mg
UC-II standardized Cartilage
40 mg

Other Ingredients

Calcium Carbonate Cellulose Cellulose Coating Stearic Acid Croscarmellose Polydextrose Titanium Dioxide color Contains Less Than 2% of

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (99% of products) Structure/Function (85% of products) Nutrient (70% of products) Approved Health (4% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

1 per day

Directions For Adult Use: Take one (1) tablet per day preferably with food.

⚠️ Warnings & Precautions

Keep out of reach of children.

Tamper Resistant: Do not use if blister seal is cut, torn or open.

Caution: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Not intended for use by persons under the age of 18.

As a reminder, discuss the supplements and medications you take with your health care providers.

🧪 Formulation Notes

Joint Health

UC-ll Collagen a unique natural source of collagen that supports joint comfort. Joint Shield 5-Loxin Advanced shows Improved Joint Comfort in 7 Days. Vitamin D3 an active & potent form of Vitamin D that helps support bone health.

Helps to: Support joint function Support joint mobility

Made to Move During the day, you move your joints in so many different ways, getting up, sitting down, bending and flexing. Osteo Bi-Flex is America's #1 Joint Health brand and supports joint comfort, so you can enjoy a range of motion for your day's activities.

Start feeling the difference in your joints in just 7 days with the power of Joint Shield! Osteo Bi-Flex is manufactured under the highest standards for product quality, purity and potency.

Joint health Shows improved joint comfort within 7 days!

UC-II collagen with Joint Shield

Free of gluten and shellfish Non-GMO

Made in the USA with select ingredients from around the world.

Advanced Triple Action

Additional Information

#1 Pharmacist recommended brand 2020-2021 U.S.News & World Report Pharmacy Times

Enjoy a Range of Motion with Osteo Bi-Flex Ease! Say goodbye to traditional joint formulas and hello to Osteo Bi-Flex Ease.

To learn more about Osteo Bi-Flex visit www.osteobiflex.com or call us toll free 1-888-vitahelp (848-2435).

Store at room temperature and avoid excessive heat.

See bottom of box for more information about our Ambassador’s Club

#1 Pharmacist recommended brand

80% smaller tablet

20 points Join the Ambassador’s Club for rewards Visit www.osteobiflex.com for more information.

Compared to Osteo Bi-Flex One Per Day tablet. Based on the results of the Pharmacy Times Survey of Pharmacists' OTC Recommendations who recommend a “joint health” dietary supplement, (2020-2021).

Based on two human studies with 5-Loxin Advanced where subjects rated their joint health over time, subjects’ joint health improved within 7 days, and continued to improve throughout the duration of the studies. Source IRI Total US - Multi Outlet: Latest 52 week ending April 26, 2020.

Product Details

UPC / SKU 0 30768 55388 3
DSLD Entry Date 2021-03-25
Product Type Other Combinations
Form Tablet or Pill
DSLD ID 242703
Data Updated 2026-04-11

Research Evidence

872 Research Sources
53 Avg Quality Score
309 Meta Analysis
309 Clinical Trial
111 Rct
71 Systematic Review
55 Guideline
4 Cochrane Review
4 Regulatory Source
2 Other
2 Narrative Review
2 Observational
1 Openfda Safety
A Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis
Meta Analysis The Cochrane database of systematic reviews 2009
A Vitamin D supplementation for prevention of mortality in adults
Meta Analysis The Cochrane database of systematic reviews 2014
A Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men
Meta Analysis The Cochrane database of systematic reviews 2014
A Vitamin D supplementation for prevention of cancer in adults
Meta Analysis The Cochrane database of systematic reviews 2014
A Interventions for preventing falls in older people in care facilities and hospitals
Meta Analysis The Cochrane database of systematic reviews 2018
A Drugs for preventing lung cancer in healthy people
Meta Analysis The Cochrane database of systematic reviews 2020
A Vitamin D supplementation for prevention of mortality in adults
Meta Analysis The Cochrane database of systematic reviews 2011
A High prevalence of vitamin D deficiency in Asia: A systematic review and meta-analysis
Meta Analysis Critical reviews in food science and nutrition 2023
A The effect of vitamin D supplementation on depressive symptoms in adults: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2023
A Interventions for preventing falls in older people living in the community
Meta Analysis The Cochrane database of systematic reviews 2009
View all evidence for Vitamin D →

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