Home/ Supplements/ Grape Seed/ Grape Seed Extract

Grape Seed Extract

product on market Capsule 21st Century Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Grape seed extract contains proanthocyanidins that may support cardiovascular health and provide antioxidant effects. Research evidence for these benefits is generally considered moderate. This ingredient profile maintains a high safety rating for most users.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Grape Seed Extract
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Vegetarian Capsule(s)
Serving Size
100
Servings
Botanical
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 100.0mg (284 products) 10 studies (A:0, B:4)

Other Ingredients

Rice Bran Oat Fiber Cellulose Contains Less Than 2% of
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: As a herbal supplement, adults take two (2) capsules with any meal, twice daily or as directed by a healthcare provider. Do not exceed recommended dosage.

Warnings & Precautions

Warning: Consult a healthcare provider prior to use if pregnant, nursing, on medications, have a medical condition or are planning a medical procedure.

Stop use and contact a physician if adverse reactions occur.

Keep out of reach of children.

Do not use if product appears to be tampered with or seal is broken.

Formulation Notes

Grape seeds contain a powerful bioflavonoid complex called proanthocyanidins, which have been shown to be a valuable aid in antioxidant support.

No added sugar, salt, yeast, preservatives, artificial flavors or colors.

100% Vegetarian.

Standardized Antioxidant support

Gluten free

Additional Information

Individual results may vary.

Store at room temperature.

Guaranteed Quality Laboratory Tested

Metadata

Product Details

UPC / SKU7 40985 21956 0
DSLD Entry Date2020-09-25
Product TypeBotanical
FormCapsule
Brand21st Century
DSLD ID233606
Data Updated2026-04-11
Research

Research Evidence

14
Research Sources
50
Avg Quality
9
Rct
2
Meta Analysis
2
Clinical Trial
1
Systematic Review
B Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers LDL Cholesterol in Patients with Mild Dyslipidemia: A Multicenter, Randomized Controlled Trial
Rct Nutrients 2023 PubMed DOI
B Efficacy of Bilberry and Grape Seed Extract Supplement Interventions to Improve Glucose and Cholesterol Metabolism and Blood Pressure in Different Populations-A Systematic Review of the Literature
Systematic Review Nutrients 2021 PubMed DOI
B The effect of grape seed extract on cardiovascular risk markers: a meta-analysis of randomized controlled trials
Meta Analysis Journal of the American Dietetic Association 2011 PubMed DOI
B The impact of grape seed extract treatment on blood pressure changes: A meta-analysis of 16 randomized controlled trials
Meta Analysis Medicine 2016 PubMed DOI
B Grape Seed Extract Positively Modulates Blood Pressure and Perceived Stress: A Randomized, Double-Blind, Placebo-Controlled Study in Healthy Volunteers
Rct Nutrients 2021 PubMed DOI
C Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: a randomised, double-blinded, two-arm, parallel, placebo-controlled trial
Rct The British journal of nutrition 2016 PubMed DOI
C Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome
Rct Metabolism: clinical and experimental 2009 PubMed DOI
C Grape seed extract supplementation along with a restricted-calorie diet improves cardiovascular risk factors in obese or overweight adult individuals: A randomized, placebo-controlled trial
Rct Phytotherapy research : PTR 2021 PubMed DOI
C The effect of polyphenol-rich chardonnay seed supplements on peripheral endothelial function.
Rct European journal of nutrition PubMed DOI
C The effects of grape seed extract supplementation on cardiovascular risk factors, liver enzymes and hepatic steatosis in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled study.
Rct BMC complementary medicine and therapies PubMed DOI
View all evidence for Grape Seed →
Compare

Similar Products

Garlic plus Grape Seed
GNC Herbal Plus · Capsule
100
Grape Seed 100 mg
GNC Nature's Fingerprint · Capsule
100
Grape Seed Extract 50 mg
Nature's Bounty · Capsule
100
Grape Seed Extract 50 mg
Sundown Naturals · Capsule
100
Grape Seed Extract
Vitabase · Capsule
100
View all Grape Seed products →
Grape Seed research Best Grape Seed All Grape Seed products More from 21st Century View on NIH DSLD →

This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.