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5-HTP 50 mg

product on market Capsule Allergy Research Group Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

L-5-Hydroxytryptophan serves as a precursor to serotonin and is used to support mood and sleep regulation. There is moderate research evidence supporting its efficacy for these purposes. The ingredient profile maintains a high safety rating for general use.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for 5-HTP 50 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
150
Servings
Amino acid/Protein
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 100.0mg (116 products) 18 studies (A:0, B:3)

Other Ingredients

Hydroxypropyl Methylcellulose Microcrystalline Cellulose L-Leucine
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Info

Product Information

Directions for Use

Suggested use As a dietary supplement, 1 capsule one to three times daily, or as directed by a healthcare practitioner.

Warnings & Precautions

Caution: Not indicated for pregnant or nursing women. Concurrent use with SSRI medications of MAO inhibitors should only be done under the guidance of a healthcare professional.

Formulation Notes

The amino acid L-5-Hydroxytryptophan. Our 5-HTP is derived from a plant source, and is carefully tested to ensure its purity.

Variations in product color may occur.

L-5-Hydroxytryptophan

Hypoallergenic

Additional Information

Keep in a cool, dry place, tightly capped.

Metadata

Product Details

UPC / SKU7 13947 72810 3
DSLD Entry Date2020-08-23
Product TypeAmino acid/Protein
FormCapsule
DSLD ID233245
Data Updated2026-04-11
Research

Research Evidence

21
Research Sources
53
Avg Quality
11
Systematic Review
6
Rct
4
Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025 PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023 PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025 PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010 PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020 PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025 PubMed DOI
View all evidence for 5 Htp →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.