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5-HTP Supreme

product on market Capsule Designs for Health Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

5-HTP serves as a precursor to serotonin, while Vitamin B-6 acts as a cofactor in its synthesis. Research provides moderate evidence that these ingredients may support mood regulation and sleep. However, overall evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for 5-HTP Supreme
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
Other Combinations
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

20 mg (1000% DV)
15.4× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
100 mg
Market median: 100.0mg (116 products) 18 studies (A:0, B:3)

Other Ingredients

Microcrystalline Cellulose Rice Flour L-Leucine
Claims

Label Claims — Verification

Unverified All Other
Info

Product Information

Directions for Use

Recommended Use: As a dietary supplement, take one capsule per day, or as directed by your health care practitioner.

Warnings & Precautions

Warning: Not recommended for use by pregnant or lactating women, or by those taking SSRI or MAOI medications.

KEEP OUT OF REACH OF CHILDREN.

Formulation Notes

Does not contain gluten.

Additional Information

HTU060

For Professional Use Only

Notice: Color, size or shape may appear different between lots.

STORE IN A COOL, DRY PLACE.

Guaranteed GMP COMPLIANT Products

Manufactured in an NSF GMP Registered Facility

Metadata

Product Details

UPC / SKU8 79452 00077 3
DSLD Entry Date2013-06-25
Product TypeOther Combinations
FormCapsule
BrandDesigns for Health
DSLD ID23193
Data Updated2026-04-11
Research

Research Evidence

21
Research Sources
53
Avg Quality
11
Systematic Review
6
Rct
4
Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025 PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023 PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025 PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010 PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020 PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025 PubMed DOI
View all evidence for 5 Htp →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.