Methylfolate 1,333 mcg DFE (800 mcg (6S)-5-Methyltetrahydrofolate) Orange Flavor by Country Life — Ingredients, Evidence & Safety

🟡 60/100

Review before taking

Folate: 1.333mg is 1.3× the Tolerable Upper Intake Level (1.0mg)
100% of ingredients have research evidence

C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Folate: 1.333mg is 1.3× the Tolerable Upper Intake Level (1.0mg)

The safety score is low because the amount of folate in this product exceeds the recommended maximum daily limit of 1.0mg.

Label Data

1 Chewable Tablet(s) Serving Size

Vitamin Product Type

100% Evidence Coverage

Supplement Facts — Evidence Check

Folate

1333 mcg (333% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 1.3× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 1.333mg UL 1.0mg

Other Ingredients

Xylitol Cellulose Stearic Acid Dextrin Orange juice concentrate natural Orange flavor Silica organic Rebaudioside A

Label Claims — Verification

❓ Nutrient

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (77% of products) Nutrient (60% of products) Approved Health (5% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Kosher Halal Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

Directions: Adults chew one (1) chewable tablet daily with or without food.

⚠️ Warnings & Precautions

Do not exceed recommended dose.

As a reminder, discuss the supplements and medications that you take with your health care providers. Caution: If you are pregnant or nursing, taking medication or planning a surgery, consult your doctor before using this product.

Stop using and consult a doctor if any adverse reactions occur. Do no accept if seal is broken.

Keep out of the reach of children.

🧪 Formulation Notes

This Methylfolate contains patented Quatrefolic - a metabolically active form of Folate. This great tasting chewable means no pills to swallow and no need for water. Formulated with a pleasant natural orange flavor.

Yes Certified gluten-free by GFCO.org

Yes Certified vegan by the AVA

Yes Kosher-Parve

Yes Certified Halal by IFANCA

No Yeast, soy or milk No Salt or sugar No Preservatives No Artificial colors, flavors or sweeteners No Magnesium stearate No GMOs

GF Certified Gluten-free

(800 mcg (6S)-5-Methyltetrahydrofolate) (6S)-5-Methyltetrahydrofolate Contains metabolically active form of Folate

Our pledge of integrity Authenticity Cleanliness Freshness Consistency Accuracy

This product has been manufactured at a GMP registered facility.

Quatrefolic

Additional Information

Yes Recyclable packaging Yes Manufacturing supports wind power

Certified B Corporation GF Certified Gluten-free IFANCA Certified M Halal K Parve (Kosher)

No pills to swallow

Store in a dry place between 59 degrees-86 degrees F.

Product Details

UPC / SKU 0 15794 06310 0

DSLD Entry Date 2020-07-23

Product Type Vitamin

Form Other (e.g. tea bag)

Brand Country Life

DSLD ID 231102

Data Updated 2026-04-11

Research Evidence

363 Research Sources

57 Avg Quality Score

187 Meta Analysis

56 Systematic Review

54 Rct

29 Guideline

26 Clinical Trial

6 Cochrane Review

2 Regulatory Source

1 Other

1 Openfda Safety

A Homocysteine-lowering interventions for preventing cardiovascular events

Meta Analysis The Cochrane database of systematic reviews 2017

PubMed DOI

A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI

A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies

Meta Analysis Digestive diseases and sciences 2021

PubMed DOI

A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis

Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021

PubMed DOI

A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Meta Analysis Nutrients 2024

PubMed DOI

A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis

Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025

PubMed DOI

A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies

Meta Analysis Critical reviews in food science and nutrition 2019

PubMed DOI

A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials

Meta Analysis Critical reviews in food science and nutrition 2022

PubMed DOI

A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants

Meta Analysis Critical reviews in food science and nutrition 2023

PubMed DOI

A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care

Meta Analysis The Cochrane database of systematic reviews 2025

PubMed DOI

View all evidence for Folate →