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Methylfolate 1,333 mcg DFE (800 mcg (6S)-5-Methyltetrahydrofolate) Orange Flavor

product on market Other (e.g. tea bag) Country Life Safety: 60/100
60/100

Review before taking

  • Folate: 1.333mg is 1.3× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Methylfolate is a bioactive form of folate used to support cellular methylation and neural development, with strong evidence for its role in preventing neural tube defects. However, a safety score of 60 suggests potential concerns regarding dosage or individual tolerance. Users should consult a professional to ensure this concentration is appropriate for their needs.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 1.333mg is 1.3× the Tolerable Upper Intake Level (1.0mg)

AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This product received a low safety score because the amount of folate exceeds the recommended tolerable upper intake level. Specifically, it provides 1.3 times the maximum daily limit suggested for safety.

Label

Product Label

Label for Methylfolate 1,333 mcg DFE (800 mcg (6S)-5-Methyltetrahydrofolate) Orange Flavor
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Chewable Tablet(s)
Serving Size
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

1333 mcg (333% DV)
Exceeds UL by 1.3× (UL: 1.0 mg) 226 studies (A:10, B:105)

Other Ingredients

Xylitol Cellulose Stearic Acid Dextrin Orange juice concentrate natural Orange flavor Silica organic Rebaudioside A
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Adults chew one (1) chewable tablet daily with or without food.

Warnings & Precautions

Do not exceed recommended dose.

As a reminder, discuss the supplements and medications that you take with your health care providers. Caution: If you are pregnant or nursing, taking medication or planning a surgery, consult your doctor before using this product.

Stop using and consult a doctor if any adverse reactions occur. Do no accept if seal is broken.

Keep out of the reach of children.

Formulation Notes

This Methylfolate contains patented Quatrefolic - a metabolically active form of Folate. This great tasting chewable means no pills to swallow and no need for water. Formulated with a pleasant natural orange flavor.

Yes Certified gluten-free by GFCO.org

Yes Certified vegan by the AVA

Yes Kosher-Parve

Yes Certified Halal by IFANCA

No Yeast, soy or milk No Salt or sugar No Preservatives No Artificial colors, flavors or sweeteners No Magnesium stearate No GMOs

GF Certified Gluten-free

(800 mcg (6S)-5-Methyltetrahydrofolate) (6S)-5-Methyltetrahydrofolate Contains metabolically active form of Folate

Our pledge of integrity Authenticity Cleanliness Freshness Consistency Accuracy

This product has been manufactured at a GMP registered facility.

Quatrefolic

Additional Information

Yes Recyclable packaging Yes Manufacturing supports wind power

Certified B Corporation GF Certified Gluten-free IFANCA Certified M Halal K Parve (Kosher)

No pills to swallow

Store in a dry place between 59 degrees-86 degrees F.

Metadata

Product Details

UPC / SKU0 15794 06310 0
DSLD Entry Date2020-07-23
Product TypeVitamin
FormOther (e.g. tea bag)
DSLD ID231102
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.