100/100
This product looks safe
- No ingredients exceed tolerable upper intake levels
- 33% of ingredients have research evidence
A
Label Compliance Grade
What the Evidence Says
✨ AI-generated · Qwen 3.6
· methodology
Pregnenolone and DHEA are precursor hormones that may support cognitive function and hormonal balance, though clinical evidence for these effects is often limited. Vitamin B3 supports cellular energy metabolism and DNA repair with strong research backing. Together, these ingredients target endocrine and metabolic pathways, but overall evidence coverage for this specific combination is low.
AI-generated summary based on research evidence. Not medical advice.
Details
Label Data
Other Combinations
Product Type
Ingredients
Supplement Facts — Evidence Check
Market median: 30.0mg (45 products)
Within RDA (0.3× RDA)
196 studies (A:5, B:63)
Market median: 50.0mg (57 products)
17 studies — no high-quality reviews
Other Ingredients
Glycerin
deionized Water
Soy Lecithin
Castor Oil
Cranberry Flavor, Natural
Mixed Tocopherols
Stevia rebaudiana extract
Potassium Sorbate
Zinc Gluconate
Trace Minerals
Claims
Label Claims — Verification
Unverified
All Other
Unverified
Structure/Function
Info
Product Information
Directions for Use
Take 1 mL (about 30 drops) orally twice daily, or as directed by your healthcare professional. Shake well.
Warnings & Precautions
Tamper-proof. Do not use if safety seal is broken or missing.
Keep out of reach of children.
Formulation Notes
Gluten-free.
Dietary Supplement
Additional Information
10080138
{recycle} Please recycle
- The Energetic Difference -
Liquid Form for Optimal Assimilation
HORMONAL SUPPORT
Store in cool, dry place out of direct sunlight.
r08-09
Metadata
Product Details
UPC / SKU3 64578 10030 3
DSLD Entry Date2013-06-25
Product TypeOther Combinations
FormLiquid
Data Updated2026-04-11
Research
Research Evidence
B
Effect of Pregnenolone vs Placebo on Self-reported Chronic Low Back Pain Among US Military Veterans: A Randomized Clinical Trial
C
Pregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder
C
Pregnenolone for cognition and mood in dual diagnosis patients
C
Reduced urine pregnenolone concentration after clinical response in patients with depression: An open-label short-term prospective study
C
Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia
Rct
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
2009
PubMed
DOI
D
Mitochondrial cytochrome P450 1B1 is involved in pregnenolone synthesis in human brain cells
Other
The Journal of biological chemistry
2023
PubMed
DOI
D
Increased steroid hormone dehydroepiandrosterone and pregnenolone levels in post-mortem brain samples of alcoholics
Other
Alcohol (Fayetteville, N.Y.)
2016
PubMed
DOI
D
Pregnenolone sulfate in the brain: a controversial neurosteroid
Narrative Review
Neurochemistry international
2008
PubMed
D
Individual differences in cognitive aging: implication of pregnenolone sulfate
Narrative Review
Progress in neurobiology
2003
PubMed
View all evidence for Pregnenolone →
This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.
