5-HTP Synergy

product on market Capsule Designs for Health 🟢 Safety: 100/100
Brand: Designs for Health
🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

1 Capsule(s) Serving Size
Other Combinations Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

10 mg (500% DV)
📊 7.7× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 10mg UL 100mg
50 mg
📊 Market median: 100.0mg (116 products) 📚 15 studies (Tier A: 0, B: 3)
This product: 50mg

Other Ingredients

Microcrystalline Cellulose Rice Flour L-Leucine

Label Claims — Verification

❓ All Other
All Other (99% of products) Structure/Function (78% of products) Nutrient (52% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Recommended Use: As a dietary supplement, take one capsule per day, or as directed by your health care practitioner.

⚠️ Warnings & Precautions

Warning: Not recommended for use by pregnant or lactating women, or by those taking SSRI or MAOI medications.

KEEP OUT OF REACH OF CHILDREN.

🧪 Formulation Notes

Does not contain gluten.

Additional Information

HTP090-1

For Professional Use Only

Guaranteed GMP COMPLIANT Products

Notice: Color, size or shape may appear different between lots.

STORE IN A COOL, DRY PLACE.

Product Details

UPC / SKU 8 79452 00075 9
DSLD Entry Date 2013-10-25
Product Type Other Combinations
Form Capsule
Brand Designs for Health
DSLD ID 22647
Data Updated 2026-04-11

Research Evidence

21 Research Sources
53 Avg Quality Score
11 Systematic Review
6 Rct
4 Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018
PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001
PubMed Cochrane
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002
PubMed Cochrane
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024
PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025
PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023
PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025
PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010
PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020
PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025
PubMed DOI
View all evidence for 5 Htp →

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