KDIR Fluidren by Systemic Formulas Bio Challenge — Ingredients, Evidence & Safety

Product Label

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Safety Alerts

⚠️ Manganese: 20mg is 1.8× the Tolerable Upper Intake Level (11mg)

ℹ️ Contains proprietary blend — exact ingredient amounts not disclosed

The safety score is low because the manganese level exceeds the recommended safe upper limit and the product uses a proprietary blend that does not disclose the exact amounts of each ingredient.

Label Data

1 Capsule(s) Serving Size

Botanical with Nutrients Product Type

33% Evidence Coverage

Supplement Facts — Evidence Check

Manganese

20 mg (1088% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 1.8× (UL: 11 mg) 📚 8 studies — no high-quality reviews

RDA 2.3mg This product: 20mg UL 11mg

Zinc

6 mg (300% DV)

✅ Within RDA (0.5× RDA of 11 mg) 📚 258 studies (Tier A: 6, B: 134)

RDA 11mg This product: 6mg UL 40mg

Proprietary Blend

696 mg

Other Ingredients

Cellulose Stearic Acid Lactose

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (100% of products) Structure/Function (74% of products) Nutrient (37% of products)

Target Groups

Vegetarian Adult (18 - 50 Years)

Product Information

📋 Directions for Use

DIRECTIONS FOR NUTRITIONAL USE: 1-2 capsules up to twice a day for 1-3 months, or as directed. Then, take as needed for maintenance. Increase the amount of liquids you drink each day while taking this product.

⚠️ Warnings & Precautions

Keep away from Heat, Sunlight and Children.

The herbs in this product are a diuretic and should be used with caution. Please consult with a health professional before using this product.

Additional Information

Keep away from Heat, Sunlight and Children.

#450 C/12

A gentle, effective support for healthy kidney activity; sustains appropriate fluid levels.

SOLD THROUGH PROFESSIONALS

MADE IN U.S.A.

veg

Product Details

UPC / SKU 6 35585 04501 8

DSLD Entry Date 2013-06-25

Product Type Botanical with Nutrients

Form Capsule

Brand Systemic Formulas Bio Challenge

DSLD ID 22174

Data Updated 2026-04-11

Research Evidence

11 Research Sources

47 Avg Quality Score

7 Rct

2 Meta Analysis

1 Regulatory Source

C Trace elements and Alzheimer dementia in population-based studies: A bibliometric and meta-analysis

Meta Analysis Environmental pollution (Barking, Essex : 1987) 2023

PubMed DOI

C Proteins involved in iron metabolism in beef cattle are affected by copper deficiency in combination with high dietary manganese, but not by copper deficiency alone

Rct Journal of animal science 2010

PubMed DOI

C Reducing mineral usage in feedlot diets for Nellore cattle: II. Impacts of calcium, phosphorus, copper, manganese, and zinc contents on intake, performance, and liver and bone status

Rct Journal of animal science 2017

PubMed DOI

C Copper, Ceruloplasmin, Zinc, and Manganese Levels in Brain and Biological Fluids from Parkinson's Disease Patients: Systematic Review and Meta-Analysis

Meta Analysis Cells 2026

PubMed DOI

C Risedronate reverses bone loss in postmenopausal women with low bone mass: results from a multinational, double-blind, placebo-controlled trial. BMD-MN Study Group

Rct The Journal of clinical endocrinology and metabolism 2000

PubMed

C Dietary Reference Intakes: Manganese

Regulatory Source IOM/NAM Dietary Reference Intakes 2000

C Vitamins and minerals intake adequacy in hematopoietic stem cell transplant: results of a randomized controlled trial.

Rct Bone marrow transplantation

PubMed DOI

C Collagen Peptides, in Association with Vitamin C, Sodium Hyaluronate, Manganese and Copper, as Part of the Rehabilitation Project in the Treatment of Chronic Low Back Pain.

Rct Endocrine, metabolic & immune disorders drug targets

PubMed DOI

C Glucosamine, chondroitin, and manganese ascorbate for degenerative joint disease of the knee or low back: a randomized, double-blind, placebo-controlled pilot study

Rct Military medicine 1999

PubMed

C Effects of a cream containing madecassoside, 5% panthenol, and copper-zinc-manganese on improving postlaser resurfacing wound healing: A split-face, randomized trial.

Rct Dermatologic therapy

PubMed DOI

View all evidence for Manganese →