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KDIR Fluidren

product on market Capsule Systemic Formulas Bio Challenge Safety: 77/100
77/100

Review before taking

  • Manganese: 20mg is 1.8× the Tolerable Upper Intake Level (11mg)
  • Contains proprietary blend — exact ingredient amounts not disclosed
  • 33% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Zinc and manganese are essential minerals that support antioxidant defenses and metabolic functions, with strong evidence supporting their general biological roles. However, the proprietary blend lacks transparency, contributing to limited evidence coverage for the overall formulation. The product maintains a favorable safety profile based on the provided score.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Manganese: 20mg is 1.8× the Tolerable Upper Intake Level (11mg)

Contains proprietary blend — exact ingredient amounts not disclosed

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This product has a lower safety score because it contains more manganese than the recommended daily upper limit. Additionally, it uses a proprietary blend, meaning the exact amounts of some ingredients are not disclosed.

Label

Product Label

Label for KDIR Fluidren
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
Botanical with Nutrients
Product Type
33%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

20 mg (1088% DV)
Exceeds UL by 1.8× (UL: 11 mg) 9 studies — no high-quality reviews
6 mg (300% DV)
Within RDA (0.5× RDA) 263 studies (A:6, B:134)
Proprietary Blend
696 mg

Other Ingredients

Cellulose Stearic Acid Lactose
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

DIRECTIONS FOR NUTRITIONAL USE: 1-2 capsules up to twice a day for 1-3 months, or as directed. Then, take as needed for maintenance. Increase the amount of liquids you drink each day while taking this product.

Warnings & Precautions

Keep away from Heat, Sunlight and Children.

The herbs in this product are a diuretic and should be used with caution. Please consult with a health professional before using this product.

Additional Information

Keep away from Heat, Sunlight and Children.

#450 C/12

A gentle, effective support for healthy kidney activity; sustains appropriate fluid levels.

SOLD THROUGH PROFESSIONALS

MADE IN U.S.A.

veg

Metadata

Product Details

UPC / SKU6 35585 04501 8
DSLD Entry Date2013-06-25
Product TypeBotanical with Nutrients
FormCapsule
BrandSystemic Formulas Bio Challenge
DSLD ID22174
Data Updated2026-04-11
Research

Research Evidence

11
Research Sources
47
Avg Quality
7
Rct
2
Meta Analysis
1
Regulatory Source
C Trace elements and Alzheimer dementia in population-based studies: A bibliometric and meta-analysis
Meta Analysis Environmental pollution (Barking, Essex : 1987) 2023 PubMed DOI
C Proteins involved in iron metabolism in beef cattle are affected by copper deficiency in combination with high dietary manganese, but not by copper deficiency alone
Rct Journal of animal science 2010 PubMed DOI
C Reducing mineral usage in feedlot diets for Nellore cattle: II. Impacts of calcium, phosphorus, copper, manganese, and zinc contents on intake, performance, and liver and bone status
Rct Journal of animal science 2017 PubMed DOI
C Copper, Ceruloplasmin, Zinc, and Manganese Levels in Brain and Biological Fluids from Parkinson's Disease Patients: Systematic Review and Meta-Analysis
Meta Analysis Cells 2026 PubMed DOI
C Risedronate reverses bone loss in postmenopausal women with low bone mass: results from a multinational, double-blind, placebo-controlled trial. BMD-MN Study Group
Rct The Journal of clinical endocrinology and metabolism 2000 PubMed
C Dietary Reference Intakes: Manganese
Regulatory Source IOM/NAM Dietary Reference Intakes 2000
C Vitamins and minerals intake adequacy in hematopoietic stem cell transplant: results of a randomized controlled trial.
Rct Bone marrow transplantation PubMed DOI
C Collagen Peptides, in Association with Vitamin C, Sodium Hyaluronate, Manganese and Copper, as Part of the Rehabilitation Project in the Treatment of Chronic Low Back Pain.
Rct Endocrine, metabolic & immune disorders drug targets PubMed DOI
C Glucosamine, chondroitin, and manganese ascorbate for degenerative joint disease of the knee or low back: a randomized, double-blind, placebo-controlled pilot study
Rct Military medicine 1999 PubMed
C Effects of a cream containing madecassoside, 5% panthenol, and copper-zinc-manganese on improving postlaser resurfacing wound healing: A split-face, randomized trial.
Rct Dermatologic therapy PubMed DOI
View all evidence for Manganese →
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Manganese research Best Manganese All Manganese products More from Systemic Formulas Bio Challenge View on NIH DSLD →

This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.