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The Best Sleep

product on market Capsule Natural Factors Three Brains Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 40% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

This blend contains botanical extracts like passionflower and skullcap, which are traditionally used to support relaxation and sleep. Research evidence for these specific ingredients is generally limited to moderate or preliminary studies. The overall evidence coverage for this specific formulation is very low.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for The Best Sleep
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Capsule(s)
Serving Size
45
Servings
Botanical
Product Type
40%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 250.0mg (60 products) 7 studies (A:0, B:1)
Skullcap extract
150 mg
California Poppy extract
125 mg
Market median: 333.0mg (166 products) 9 studies (A:0, B:2)
Linden extract
100 mg

Other Ingredients

Microcrystalline Cellulose Vegetarian Capsule Magnesium Stearate Silica
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Usage: 2 capsules per day before bedtime or as directed by a health professional.

Warnings & Precautions

Cautions: As with any supplement, consult your health professional before use if you are pregnant, breastfeeding, or trying to conceive, or if you are taking medication, have a medical condition, or anticipate a surgery.

Keep out of the reach of children.

Sealed for your protection. Do not use if seal is broken.

Formulation Notes

Three Brains is a line of supplements designed to support the critical relationship between our head, heart, and gut. Together, these three "brains" influence our cognition and support a healthy mind.

The Best Sleep combines five non-habit-forming natural ingredients that have been traditionally used by herbalists as mild sleep aids, especially in cases of restlessness or occasional sleeplessness due to everyday mental stress. The ingredients in this unique formula also have an analgesic effect that further promotes relaxed and restful sleep.

Manufactured by Natural Factors to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.

Contains no artificial colors, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs.

Suitable for vegetarians/vegans.

Supports relaxation & promotes restful sleep

Additional Information

isura Non-GMO - Mass Spec Documentation Lab tested

For freshness, store in a cool, dry place.

Recyclable container and label. Product of Canada

Purity & Potency Guaranteed

Metadata

Product Details

UPC / SKU0 68958 03058 6
DSLD Entry Date2020-05-22
Product TypeBotanical
FormCapsule
DSLD ID220758
Data Updated2026-04-11
Research

Research Evidence

7
Research Sources
47
Avg Quality
6
Rct
1
Meta Analysis
B Passiflora for anxiety disorder
Meta Analysis The Cochrane database of systematic reviews 2007 PubMed
C Effects of Passiflora incarnata Linnaeus on polysomnographic sleep parameters in subjects with insomnia disorder: a double-blind randomized placebo-controlled study
Rct International clinical psychopharmacology 2020 PubMed DOI
C Effects of Passiflora incarnata and Valeriana officinalis in the control of anxiety due to tooth extraction: a randomized controlled clinical trial
Rct Oral and maxillofacial surgery 2024 PubMed DOI
C A double-blind, placebo-controlled investigation of the effects of Passiflora incarnata (passionflower) herbal tea on subjective sleep quality
Rct Phytotherapy research : PTR 2011 PubMed DOI
C Effects of passiflora incarnata and midazolam for control of anxiety in patients undergoing dental extraction
Rct Medicina oral, patologia oral y cirugia bucal 2017 PubMed
C The chronic effects of a combination of herbal extracts (Euphytose®) on psychological mood state and response to a laboratory stressor: A randomised, placebo-controlled, double blind study in healthy humans.
Rct Journal of psychopharmacology (Oxford, England) PubMed DOI
D Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam
Rct Journal of clinical pharmacy and therapeutics 2001 PubMed
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.