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B12 Methylcobalamin 1000 mcg

product on market Tablet or Pill Natural Factors Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Methylcobalamin is a bioactive form of vitamin B12 that supports nerve function and red blood cell formation. There is strong clinical evidence supporting its role in preventing deficiency and maintaining neurological health. This specific formulation provides a standard dose for supplementation.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for B12 Methylcobalamin 1000 mcg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

1000 mcg (41667% DV)
416.7× RDA — above typical dose 139 studies (A:1, B:44)

Other Ingredients

Lactose Microcrystalline Cellulose Croscarmellose Sodium Magnesium Stearate
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Usage: Chew and dissolve 1 tablet per day in the mouth before swallowing or as directed by a health professional.

Check with your doctor or health professional on what is the best form and potency for you.

Warnings & Precautions

Cautions: As with any supplement, consult your health professional before use if you are pregnant, breastfeeding or trying to conceive, or if you are taking medication, have a medical condition or anticipate a surgery.

Keep out of the reach of children.

Sealed for your protection. Do not use if seal is broken.

Contains milk.

Formulation Notes

Manufactured by Natural Factors to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.

Contains no artificial colors, preservatives, or sweeteners; no starch, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, salt, tree nuts, or GMOs.

Suitable for vegetarians.

Quick dissolve

The most metabolically active form

For People with B12 deficiencies it is popular to have injectable vitamin B12; however, research supports that oral administration of an appropriate dosage has been shown to produce as good of results as injectable preparations in treating vitamin B12 deficiency. Methylcobalamin (vitamin B12) is active immediately upon absorption, while other forms (e.g., cyanocobalamin) must be converted to methylcobalamin in a two-step process. Methylcobolamin demonstrates exceptional activity in areas where other forms are simply not active. B12 supplementation is recommended for vegetarians and those with B12 deficiency. It helps form red blood cells, prevent vitamin B12 deficiency and helps maintain good health. In people with low levels of B12, supplementation is very effective in improving energy levels and restoring mental function.

isura This product has passed the most rigorous testing in the world for contaminants and quality. isura.ca

Additional Information

isura Non-GMO - Mass spec Documentation - Lab tested

For freshness, store in a cool, dry place.

Product of Canada Recyclable container and label.

Purity & Potency Guaranteed

R4

Metadata

Product Details

UPC / SKU0 68958 01243 8
DSLD Entry Date2020-05-22
Product TypeVitamin
FormTablet or Pill
DSLD ID220095
Data Updated2026-04-11
Research

Research Evidence

237
Research Sources
53
Avg Quality
83
Meta Analysis
74
Systematic Review
45
Rct
29
Clinical Trial
2
Guideline
2
Regulatory Source
1
Openfda Safety
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
A Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression
Meta Analysis Nutrients 2021 PubMed DOI
A Efficacy of different routes of vitamin B12 supplementation for the treatment of patients with vitamin B12 deficiency: A systematic review and network meta-analysis
Systematic Review Irish journal of medical science 2024 PubMed DOI
B Helicobacter pylori infection and micronutrient deficiency in pregnant women: a systematic review and meta-analysis
Meta Analysis BMJ open gastroenterology 2020 PubMed DOI
B Vitamin B12 supplementation during pregnancy for maternal and child health outcomes
Systematic Review The Cochrane database of systematic reviews 2024 PubMed DOI
B A comprehensive review and meta-regression analysis of randomized controlled trials examining the impact of vitamin B12 supplementation on homocysteine levels
Meta Analysis Nutrition reviews 2024 PubMed DOI
B Relationship between vitamin B12 levels and motor development: A systematic review
Systematic Review Clinical nutrition ESPEN 2024 PubMed DOI
B Vitamin B12, folate, and homocysteine in metabolic syndrome: a systematic review and meta-analysis
Meta Analysis Frontiers in endocrinology 2023 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.