5-HTP

product on market Capsule BRI Nutrition Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

5-HTP serves as a precursor to serotonin and is researched for its role in supporting mood and sleep. There is moderate evidence suggesting its effectiveness in managing certain depressive symptoms. The current evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for 5-HTP
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Vegetarian Capsule(s)
Serving Size
120
Servings
Amino acid/Protein
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

100 mg
Market median: 100.0mg (116 products) 18 studies (A:0, B:3)

Other Ingredients

Rice Flour Vegetable Cellulose
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use: As a dietary supplement, take 1 (one) capsule daily, preferably on an empty stomach at bedtime.

Warnings & Precautions

Warning: If you are currently taking antidepressant medications, please consult a physician prior to use.

May cause drowsiness.

Keep out of the reach of children and pets

Keep out of the reach of children and pets

Formulation Notes

Potent: 100 mg 5-hydroxytryptophan (griffonia simplicifolia) What it is: 5-HTP (a.k.a. 5-hydroxytryptophan), the intermediate metabolite between the amino acid l-tryptophan and serotonin, is extracted from the bean of an African plant (griffonia simplicifolia).

5-HTP helps your brain produce serotonin, a neurotransmitter involved in sending messages through the nervous system that contribute to your mood and well-being. Pure & natural Extra Strength Helps your brain produce serotonin Supports positive mood

100 mg 5-hydroxytryptophan

Contains no: Sugar, salt, yeast, wheat, gluten, corn, soy, milk, egg, shellfish or preservatives.

Additional Information

Quality Value Service Purity

Store in a cool, dry place.

Please recycle.

Good Manufacturing Practice Sourced from a GMP Certified Facility Quality Assured

Made in USA

100% satisfaction guaranteed

Metadata

Product Details

UPC / SKUX000RTQ5ZT
DSLD Entry Date2020-04-23
Product TypeAmino acid/Protein
FormCapsule
DSLD ID218961
Data Updated2026-04-11
Research

Research Evidence

21
Research Sources
53
Avg Quality
11
Systematic Review
6
Rct
4
Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025 PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023 PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025 PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010 PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020 PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025 PubMed DOI
View all evidence for 5 Htp →
Compare

Similar Products

View all 5 Htp products →

This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.