🟢 80/100

This product is generally safe

  • Niacin: 100mg is 2.9× the Tolerable Upper Intake Level (35mg)
  • 50% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 100mg is 2.9× the Tolerable Upper Intake Level (35mg)

Label Data

1 Tablet(s) Serving Size
Single Vitamin and Mineral Product Type
50% Evidence Coverage

Supplement Facts — Evidence Check

100 mg (625% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 2.9× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 100mg UL 35mg
Calcium
35 mg (3% DV)

Other Ingredients

Dicalcium Phosphate Microcrystalline Cellulose Talc Stearic Acid

Label Claims — Verification

Nutrient
All Other
All Other (97% of products) Structure/Function (86% of products) Nutrient (36% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

Directions: Adults only: One tablet daily as a dietary supplement, or as directed by a physician.

⚠️ Warnings & Precautions

Tamper resistant - Do not use if imprinted safety seal under cap is broken or missing

Caution: Niacin may cause temporary flushing, itching and tingling, feelings of warmth and headache, particularly when beginning, increasing dose, or changing brand of niacin. These effects seldom require discontinuing niacin use. Skin rash, upset stomach, and low blood pressure when standing are less common symptoms; if they persist, contact a physician.

Keep out of reach of children

🧪 Formulation Notes

New formula

Free of sugar, starch, sodium, soy, gluten, preservatives, yeast, corn, animal by-products, artificial colors and flavors.

Additional Information

To preserve quality and freshness, keep bottle tightly closed. Store between 15 degrees- 30 degrees C (59 degrees- 86 degrees F).

50/60

Product Details

UPC / SKU 0 05364 07601 2
DSLD Entry Date 2020-04-23
Product Type Single Vitamin and Mineral
Form Tablet or Pill
Brand Rugby
DSLD ID 218785
Data Updated 2026-04-11

Research Evidence

241 Research Sources
55 Avg Quality Score
113 Meta Analysis
75 Systematic Review
32 Rct
11 Clinical Trial
3 Other
3 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016
View all evidence for Niacin →

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