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HCl-Plus

product on market Tablet or Pill Biotics Research Corporation Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 40% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula combines betaine, pepsin, and glutamic acid to support digestive enzyme activity and gastric acid production. Research provides moderate evidence for these ingredients in managing hypochlorhydria, while vitamin B6 supports metabolic processes. Overall evidence coverage for this specific combination is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for HCl-Plus
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
Other Combinations
Product Type
40%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

2 mg (100% DV)
1.5× RDA — within safe limits 114 studies (A:3, B:35)
115 mg
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews
Glutamic Acid
50 mg
Market median: 4002.0mg (1 products) 21 studies (A:0, B:2)
Pepsin
10 mg

Other Ingredients

Vegetable culture Cellulose modified Cellulose Gum Stearic Acid Silica
Claims

Label Claims — Verification

Unverified All Other
Info

Product Information

Directions for Use

RECOMMENDATION: One (1) tablet with meals as a dietary supplement or as otherwise directed by a healthcare professional.

Warnings & Precautions

KEEP OUT OF REACH OF CHILDREN

Additional Information

Store in a cool, dry area.

Sealed with an imprinted safety seal for your protection.

Rev. 1/08

Metadata

Product Details

DSLD Entry Date2013-05-24
Product TypeOther Combinations
FormTablet or Pill
BrandBiotics Research Corporation
DSLD ID21842
Data Updated2026-04-11
Research

Research Evidence

153
Research Sources
55
Avg Quality
71
Systematic Review
51
Meta Analysis
19
Rct
6
Clinical Trial
2
Other
2
Regulatory Source
1
Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016 PubMed DOI
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020 PubMed DOI
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022 PubMed DOI
View all evidence for Vitamin B6 →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.