Home/ Supplements/ Vitamin B12/ Methyl B-12 HP

Methyl B-12 HP

product on market Lozenge NuMedica Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Vitamin B12 is essential for nerve function and red blood cell formation. There is strong evidence supporting its role in maintaining cognitive health and energy metabolism. However, the overall evidence coverage for this specific product profile is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Methyl B-12 HP
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Lozenge(s)
Serving Size
60
Servings
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

5 mg (83333% DV)
2083.3× RDA — above typical dose 139 studies (A:1, B:44)

Other Ingredients

Xylitol Sorbitol Cellulose Citric Acid Stearic Acid Natural flavors Magnesium Stearate
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Chew or hold one lozenge in mouth per day until dissolved or as directed by your healthcare practitioner.

Warnings & Precautions

Caution: Keep out of reach of children.

Formulation Notes

Methyl B-12 HP is a great tasting, sublingual lozenge providing 5 mg (5,000 mcg) of Vitamin B12 in the active, methylcobalamin form. This active methyl form has metabolic advantages over the forms, including more cobalamin deposited in tissue than with the cyanocobalamin form. Vitamin B-12 is a water-soluble vitamin necessary for the maintenance of a healthy nervous system, enhanced cognition, and and for the metabolic utilization of fats and proteins. It is also essential for the synthesis of DNA during cell division and therefore is especially important for rapidly multiplying cells, such as blood cells. In addition, it may support healthy homocysteine levels, cardiovascular health and neurological health.

Supports healthy homocysteine levels

Powerful cognitive support

This formula meets or exceeds cGMP quality standards.

Does Not Contain: Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soy.

B Activated B-vitamins

GF Gluten-free

Vegetarian

Additional Information

Advancing nutrition Professional quality formulas

Storage: Keep tightly closed in a cool, dry place.

Metadata

Product Details

UPC / SKU8 12527 01129 8
DSLD Entry Date2020-02-26
Product TypeVitamin
FormLozenge
BrandNuMedica
DSLD ID213611
Data Updated2026-04-11
Research

Research Evidence

237
Research Sources
53
Avg Quality
83
Meta Analysis
74
Systematic Review
45
Rct
29
Clinical Trial
2
Guideline
2
Regulatory Source
1
Openfda Safety
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
A Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression
Meta Analysis Nutrients 2021 PubMed DOI
A Efficacy of different routes of vitamin B12 supplementation for the treatment of patients with vitamin B12 deficiency: A systematic review and network meta-analysis
Systematic Review Irish journal of medical science 2024 PubMed DOI
B Helicobacter pylori infection and micronutrient deficiency in pregnant women: a systematic review and meta-analysis
Meta Analysis BMJ open gastroenterology 2020 PubMed DOI
B Vitamin B12 supplementation during pregnancy for maternal and child health outcomes
Systematic Review The Cochrane database of systematic reviews 2024 PubMed DOI
B A comprehensive review and meta-regression analysis of randomized controlled trials examining the impact of vitamin B12 supplementation on homocysteine levels
Meta Analysis Nutrition reviews 2024 PubMed DOI
B Relationship between vitamin B12 levels and motor development: A systematic review
Systematic Review Clinical nutrition ESPEN 2024 PubMed DOI
B Vitamin B12, folate, and homocysteine in metabolic syndrome: a systematic review and meta-analysis
Meta Analysis Frontiers in endocrinology 2023 PubMed DOI
View all evidence for Vitamin B12 →
Compare

Similar Products

Timed Release B-12 1500 mg
Vitamin World · Lozenge
100
Natural Berry Flavor Methyl B-12 1,000 mcg
VitaCeutical Labs · Lozenge
100
B-12 Lozenge 1,000 mcg
VitaCeutical Labs · Lozenge
100
High Potency Sublingual Vitamin B 12 2500 mcg
Member's Mark · Lozenge
100
Methylcobalamin B-12 5000 mcg
Vitamin World · Lozenge
100
View all Vitamin B12 products →
Vitamin B12 research Best Vitamin B12 All Vitamin B12 products More from NuMedica View on NIH DSLD →

This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.