Endothelial Defense Pomegranate Complete by Life Extension — Ingredients, Evidence & Safety

Product Label

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Safety Alerts

ℹ️ Contains proprietary blend — exact ingredient amounts not disclosed

Label Data

2 Softgel(s) Serving Size

30 Servings

Other Combinations Product Type

44% Evidence Coverage

Supplement Facts — Evidence Check

Calories

25 Calorie(s)

Total Fat

1.5 Gram(s) (2% DV)

Total Carbohydrates

1.5 Gram(s) (1% DV)

Protein

1 Gram(s) (1% DV)

Superoxide Dismutase/Gliadin Complex

500 mg

Cardiose Flavonoid Glycoside

500 mg

📊 Market median: 500.0mg (283 products) 📚 173 studies (Tier A: 0, B: 62)

This product: 500mg

Pomella Pomegranate extract

400 mg

📊 Market median: 250.0mg (182 products) 📚 10 studies (Tier A: 0, B: 2)

This product: 400mg

Proprietary Pomegranate Blend

137.5 mg

📊 Market median: 250.0mg (182 products) 📚 10 studies (Tier A: 0, B: 2)

This product: 137.5mg

Pomegranate 5:1 extract

100 mg

📊 Market median: 250.0mg (182 products) 📚 10 studies (Tier A: 0, B: 2)

This product: 100mg

Other Ingredients

extra virgin Olive Oil Gelatin Maltodextrin Glycerin Sunflower Lecithin purified Water Carob color Beeswax

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (97% of products) Structure/Function (86% of products) Nutrient (28% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Read the entire label and follow directions carefully prior to use. Directions: Take two (2) softgels daily before breakfast, or as recommended by a healthcare practitioner.

⚠️ Warnings & Precautions

Caution: Do not take this product if you are allergic to wheat or gluten.

Warnings: Keep out of reach of children.

Do not exceed recommended dose. Do not purchase if outer seal is broken or damaged.

Contains wheat

When using nutritional supplements, please consult with your physician if you are undergoing treatment or if you are pregnant or lactating.

🧪 Formulation Notes

Non-GMO

Comprehensive support for nitric oxide production and vascular health

Additional Information

Scan for product info

Store tightly closed in a cool, dry place.

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Product Details

UPC / SKU 7 37870 20976 8

DSLD Entry Date 2020-01-25

Product Type Other Combinations

Form Softgel Capsule

Brand Life Extension

DSLD ID 210815

Data Updated 2026-04-11

Research Evidence

18 Research Sources

47 Avg Quality Score

8 Clinical Trial

6 Rct

3 Meta Analysis

1 Systematic Review

B The effect of pomegranate juice on clinical signs, matrix metalloproteinases and antioxidant status in patients with knee osteoarthritis

Rct Journal of the science of food and agriculture 2016

PubMed DOI

B Impact of pomegranate juice on blood pressure: A systematic review and meta-analysis

Meta Analysis Phytotherapy research : PTR 2023

PubMed DOI

C Effects of pomegranate juice consumption on blood pressure and lipid profile in patients with type 2 diabetes: A single-blind randomized clinical trial

Rct Clinical nutrition ESPEN 2019

PubMed DOI

C The effects of pomegranate consumption on blood pressure in adults: A systematic review and meta-analysis

Meta Analysis Phytotherapy research : PTR 2024

PubMed DOI

C Evidence for the effectiveness of pomegranate supplementation for blood pressure management is weak: A systematic review of randomized clinical trials

Systematic Review Nutrition research (New York, N.Y.) 2017

PubMed DOI

C Effects of pomegranate juice on blood pressure: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Pharmacological research 2017

PubMed DOI

C Pomegranate juice is potentially better than apple juice in improving antioxidant function in elderly subjects

Rct Nutrition research (New York, N.Y.) 2008

PubMed DOI

C Exploring Unconventional Plant-Derived Metabolites for Glycemic Control: the Case of Pomegranate

Clinical Trial ClinicalTrials.gov 2024

ClinicalTrials.gov

C Acute effects of pomegranate extract on postprandial lipaemia, vascular function and blood pressure

Rct Plant foods for human nutrition (Dordrecht, Netherlands) 2012

PubMed DOI

C The impact of supplementation with pomegranate fruit (Punica granatum L.) juice on selected antioxidant parameters and markers of iron metabolism in rowers

Rct Journal of the International Society of Sports Nutrition 2018

PubMed DOI

View all evidence for Pomegranate →