🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

Product Label

📸

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Label Data

1 Tablet(s) Serving Size
Non-Nutrient/Non-Botanical Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

5 mg
📊 Market median: 3.0mg (984 products) 📚 236 studies (Tier A: 2, B: 109)
This product: 5mg UL 10mg

Other Ingredients

Dibasic Calcium Phosphate Sodium Starch Glycolate Magnesium Stearate Croscarmellose Sodium

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (100% of products) Structure/Function (86% of products) Nutrient (7% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

When to take: Suggested use: Consult your health care professional before use. Take one tablet one hour before bedtime. Do not exceed one tablet daily unless recommended by a health care professional. For easier swallowing, take with water before and during ingestion.

M Maximum 5 mg - For short-term use (2-5 days) to help support sleep for healthy adults who experience trouble sleeping due to interruption in normal sleep patterns (e.g. jet lag/shift work). For more information, visit NatureMade.com.

⚠️ Warnings & Precautions

Do not exceed one tablet daily unless recommended by a health care professional.

Interactions: Melatonin should be used with caution when combined with medications, including: antidepressants, antianxiety medications, diabetes medications, narcotics, blood pressure medication, and asthma medication. If you are using these or any other medications, please consult with your physician prior to using melatonin.

Warning statement: Do not use this product unless advised by a physician if you are pregnant, attempting to become pregnant, nursing; or if you are taking any medications or have any chronic disease, including hypertension (high blood pressure), diabetes, or an endocrine, autoimmune, depressive, bleeding or seizure disorder.

Do not drive a motor vehicle or operate machinery when taking melatonin.

Not intended for individuals under the age of 18 years.

Consult a health care professional if you are experiencing persistent sleep difficulties.

Given that no two people are alike, if you are taking any medications you should be aware that potential drug-nutrient interactions may occur and are encouraged to consult a health care professional before using this product. Combining certain prescription drugs and dietary supplements can lead to undesirable effects such as:

Keep out of reach of children.

Do not use if imprinted seal under cap is broken or missing.

Do not take melatonin while operating a motor vehicle or machinery.

🧪 Formulation Notes

Nature Made Maximum Strength Melatonin provides 5 mg of Melatonin, a hormone produced in the pineal gland, which helps to regulate sleep and wake cycles.

No color added No artificial flavors No preservatives No yeast Gluten free

Additional Information

USP Verified Dietary Supplement

Maximum strength for short-term use to help support sleep

Strength levels of melatonin R Regular 1 mg or below E Extra above 1 mg up to 3 mg M Maximum above 3 mg up 5 mg

Keep bottle tightly closed. Store in a cool, dry place and away from direct sunlight.

Tableted and quality tested in the U.S.A. USP has tested and verified ingredients, potency, and manufacturing process. USP sets official standards for dietary supplements. www.uspverified.org. Valid only for U.S. and Puerto Rico residents.

Product Details

DSLD Entry Date 2019-11-21
Product Type Non-Nutrient/Non-Botanical
Form Tablet or Pill
Brand Nature Made
DSLD ID 209485
Data Updated 2026-04-11

Research Evidence

291 Research Sources
55 Avg Quality Score
129 Meta Analysis
93 Systematic Review
51 Rct
11 Clinical Trial
2 Other
2 Regulatory Source
1 Openfda Safety
A Interventions for preventing delirium in hospitalised non-ICU patients
Meta Analysis The Cochrane database of systematic reviews 2016
A Melatonin for preoperative and postoperative anxiety in adults
Meta Analysis The Cochrane database of systematic reviews 2020
A Effect of melatonin on quality of life and symptoms in patients with cancer: a systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ open 2022
B Pharmacological interventions for prevention of weight gain in people with schizophrenia
Meta Analysis The Cochrane database of systematic reviews 2022
B Melatonin for pre- and postoperative anxiety in adults
Meta Analysis The Cochrane database of systematic reviews 2015
B Prevention of depression in adults with long-term physical conditions
Meta Analysis The Cochrane database of systematic reviews 2021
B Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis
Systematic Review Lancet (London, England) 2022
B Does melatonin administration reduce the incidence of postoperative delirium in adults? Systematic review and meta-analysis
Meta Analysis BMJ open 2023
B Second-generation antidepressants for preventing seasonal affective disorder in adults
Meta Analysis The Cochrane database of systematic reviews 2015
B Interventions for preventing type 2 diabetes in adults with mental disorders in low- and middle-income countries
Meta Analysis The Cochrane database of systematic reviews 2021
View all evidence for Melatonin →

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