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Melatonin Maximum Strength 5 mg

product on market Tablet or Pill Nature Made Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Melatonin is a hormone that helps regulate sleep-wake cycles and may reduce the time it takes to fall asleep. There is strong evidence supporting its efficacy for short-term sleep management and jet lag. This ingredient is generally recognized as safe for most adults when used as directed.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Melatonin Maximum Strength 5 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
Non-Nutrient/Non-Botanical
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

5 mg
Market median: 3.0mg (984 products) 240 studies (A:2, B:109)

Other Ingredients

Dibasic Calcium Phosphate Sodium Starch Glycolate Magnesium Stearate Croscarmellose Sodium
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

When to take: Suggested use: Consult your health care professional before use. Take one tablet one hour before bedtime. Do not exceed one tablet daily unless recommended by a health care professional. For easier swallowing, take with water before and during ingestion.

M Maximum 5 mg - For short-term use (2-5 days) to help support sleep for healthy adults who experience trouble sleeping due to interruption in normal sleep patterns (e.g. jet lag/shift work). For more information, visit NatureMade.com.

Warnings & Precautions

Do not exceed one tablet daily unless recommended by a health care professional.

Interactions: Melatonin should be used with caution when combined with medications, including: antidepressants, antianxiety medications, diabetes medications, narcotics, blood pressure medication, and asthma medication. If you are using these or any other medications, please consult with your physician prior to using melatonin.

Warning statement: Do not use this product unless advised by a physician if you are pregnant, attempting to become pregnant, nursing; or if you are taking any medications or have any chronic disease, including hypertension (high blood pressure), diabetes, or an endocrine, autoimmune, depressive, bleeding or seizure disorder.

Do not drive a motor vehicle or operate machinery when taking melatonin.

Not intended for individuals under the age of 18 years.

Consult a health care professional if you are experiencing persistent sleep difficulties.

Given that no two people are alike, if you are taking any medications you should be aware that potential drug-nutrient interactions may occur and are encouraged to consult a health care professional before using this product. Combining certain prescription drugs and dietary supplements can lead to undesirable effects such as:

Keep out of reach of children.

Do not use if imprinted seal under cap is broken or missing.

Do not take melatonin while operating a motor vehicle or machinery.

Formulation Notes

Nature Made Maximum Strength Melatonin provides 5 mg of Melatonin, a hormone produced in the pineal gland, which helps to regulate sleep and wake cycles.

No color added No artificial flavors No preservatives No yeast Gluten free

Additional Information

USP Verified Dietary Supplement

Maximum strength for short-term use to help support sleep

Strength levels of melatonin R Regular 1 mg or below E Extra above 1 mg up to 3 mg M Maximum above 3 mg up 5 mg

Keep bottle tightly closed. Store in a cool, dry place and away from direct sunlight.

Tableted and quality tested in the U.S.A. USP has tested and verified ingredients, potency, and manufacturing process. USP sets official standards for dietary supplements. www.uspverified.org. Valid only for U.S. and Puerto Rico residents.

Metadata

Product Details

DSLD Entry Date2019-11-21
Product TypeNon-Nutrient/Non-Botanical
FormTablet or Pill
DSLD ID209485
Data Updated2026-04-11
Research

Research Evidence

291
Research Sources
55
Avg Quality
129
Meta Analysis
93
Systematic Review
51
Rct
11
Clinical Trial
2
Other
2
Regulatory Source
1
Openfda Safety
A Interventions for preventing delirium in hospitalised non-ICU patients
Meta Analysis The Cochrane database of systematic reviews 2016 PubMed DOI
A Melatonin for preoperative and postoperative anxiety in adults
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
A Effect of melatonin on quality of life and symptoms in patients with cancer: a systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ open 2022 PubMed DOI
B Pharmacological interventions for prevention of weight gain in people with schizophrenia
Meta Analysis The Cochrane database of systematic reviews 2022 PubMed DOI
B Melatonin for pre- and postoperative anxiety in adults
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Prevention of depression in adults with long-term physical conditions
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis
Systematic Review Lancet (London, England) 2022 PubMed DOI
B Does melatonin administration reduce the incidence of postoperative delirium in adults? Systematic review and meta-analysis
Meta Analysis BMJ open 2023 PubMed DOI
B Second-generation antidepressants for preventing seasonal affective disorder in adults
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Interventions for preventing type 2 diabetes in adults with mental disorders in low- and middle-income countries
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.