Berberine HCl 500 mg by The Vitamin Shoppe — Ingredients, Evidence & Safety

🟢 100/100

This product looks safe

No ingredients exceed tolerable upper intake levels
100% of ingredients have research evidence

A Label Compliance Grade

Product Label

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Label Data

1 Vegetable Capsule(s) Serving Size

Non-Nutrient/Non-Botanical Product Type

100% Evidence Coverage

Supplement Facts — Evidence Check

Berberine HCl

500 mg

📊 Market median: 500.0mg (234 products) 📚 95 studies (Tier A: 0, B: 35)

This product: 500mg

Other Ingredients

Vegetable Capsule Microcrystalline Cellulose Magnesium Stearate Silicon Dioxide Stearic Acid

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (100% of products) Structure/Function (86% of products) Nutrient (4% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

Directions: Take one (1) vegetable capsule daily, with a meal.

⚠️ Warnings & Precautions

Keep out of reach of children.

Tamper evident Do not use if outer seal is broken or missing.

Warning: Consult your healthcare provider prior to use if you are pregnant, nursing, taking any medication or have any medical conditions.

🧪 Formulation Notes

Blood sugar support Cardiovascular health Immune support

Gluten-free Dairy-free Soy-free Nut-free Does not contain: Gluten, sugar, salt, animal derivatives, artificial colors or flavors.

Berberine is a naturally occurring plant alkaloid. Berberine plays an important role in blood sugar (glucose) metabolism and cardiovascular health.

Additional Information

Herb

Store in a cool, dry place.

Quality promise Tested & trusted

Product Details

UPC / SKU 7 66536 03919 7

DSLD Entry Date 2019-11-21

Product Type Non-Nutrient/Non-Botanical

Form Capsule

Brand The Vitamin Shoppe

DSLD ID 208835

Data Updated 2026-04-11

Research Evidence

98 Research Sources

55 Avg Quality Score

48 Systematic Review

39 Meta Analysis

4 Rct

4 Clinical Trial

1 Other

1 Narrative Review

1 Openfda Safety

B Efficacy and safety of berberine for dyslipidaemias: A systematic review and meta-analysis of randomized clinical trials

Meta Analysis Phytomedicine : international journal of phytotherapy and phytopharmacology 2018

PubMed DOI

B Effects berberine-silymarin on liver enzymes: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Clinical nutrition ESPEN 2022

PubMed DOI

B Efficacy and safety of berberine for several cardiovascular diseases: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Phytomedicine : international journal of phytotherapy and phytopharmacology 2023

PubMed DOI

B Effect of Berberine on C-reactive protein: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Complementary therapies in medicine 2019

PubMed DOI

B Overall and Sex-Specific Effect of Berberine on Glycemic and Insulin-Related Traits: a Systematic Review and Meta-Analysis of Randomized Controlled Trials

Meta Analysis The Journal of nutrition 2023

PubMed DOI

B The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review

Meta Analysis Journal of translational medicine 2024

PubMed DOI

B Berberine Effects in Pre-Fibrotic Stages of Non-Alcoholic Fatty Liver Disease-Clinical and Pre-Clinical Overview and Systematic Review of the Literature

Systematic Review International journal of molecular sciences 2024

PubMed DOI

B Efficacy and Safety of Berberine Alone or Combined with Statins for the Treatment of Hyperlipidemia: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials

Meta Analysis The American journal of Chinese medicine 2019

PubMed DOI

B Effects of Berries, Phytochemicals, and Probiotics on Atherosclerosis through Gut Microbiota Modification: A Meta-Analysis of Animal Studies

Meta Analysis International journal of molecular sciences 2023

PubMed DOI

B Berberine Ursodeoxycholate for the Treatment of Type 2 Diabetes: A Randomized Clinical Trial

Rct JAMA network open 2025

PubMed DOI

View all evidence for Berberine →