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Berberine HCl 500 mg

product on market Capsule The Vitamin Shoppe Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Berberine HCl is supported by moderate to strong evidence for its ability to help manage blood glucose levels and improve insulin sensitivity. Research indicates it may also support healthy lipid metabolism. These effects are primarily attributed to its influence on AMPK activation within the body.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Berberine HCl 500 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Vegetable Capsule(s)
Serving Size
Non-Nutrient/Non-Botanical
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

500 mg
Market median: 500.0mg (234 products) 95 studies (A:0, B:35)

Other Ingredients

Vegetable Capsule Microcrystalline Cellulose Magnesium Stearate Silicon Dioxide Stearic Acid
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take one (1) vegetable capsule daily, with a meal.

Warnings & Precautions

Warning: Consult your healthcare provider prior to use if you are pregnant, nursing, taking any medication or have any medical conditions.

Keep out of reach of children.

Tamper evident Do not use if outer seal is broken or missing.

Formulation Notes

Blood sugar support Cardiovascular health Immune support

Gluten-free Dairy-free Soy-free Nut-free Does not contain: Gluten, sugar, salt, animal derivatives, artificial colors or flavors.

Berberine is a naturally occurring plant alkaloid. Berberine plays an important role in blood sugar (glucose) metabolism and cardiovascular health.

Additional Information

Herb

Store in a cool, dry place.

Metadata

Product Details

UPC / SKU7 66536 03592 2
DSLD Entry Date2019-12-22
Product TypeNon-Nutrient/Non-Botanical
FormCapsule
BrandThe Vitamin Shoppe
DSLD ID208764
Data Updated2026-04-11
Research

Research Evidence

98
Research Sources
55
Avg Quality
48
Systematic Review
39
Meta Analysis
4
Rct
4
Clinical Trial
1
Other
1
Narrative Review
1
Openfda Safety
B Efficacy and safety of berberine for dyslipidaemias: A systematic review and meta-analysis of randomized clinical trials
Meta Analysis Phytomedicine : international journal of phytotherapy and phytopharmacology 2018 PubMed DOI
B Effects berberine-silymarin on liver enzymes: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition ESPEN 2022 PubMed DOI
B Efficacy and safety of berberine for several cardiovascular diseases: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 PubMed DOI
B Effect of Berberine on C-reactive protein: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2019 PubMed DOI
B Overall and Sex-Specific Effect of Berberine on Glycemic and Insulin-Related Traits: a Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis The Journal of nutrition 2023 PubMed DOI
B The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review
Meta Analysis Journal of translational medicine 2024 PubMed DOI
B Berberine Effects in Pre-Fibrotic Stages of Non-Alcoholic Fatty Liver Disease-Clinical and Pre-Clinical Overview and Systematic Review of the Literature
Systematic Review International journal of molecular sciences 2024 PubMed DOI
B Efficacy and Safety of Berberine Alone or Combined with Statins for the Treatment of Hyperlipidemia: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials
Meta Analysis The American journal of Chinese medicine 2019 PubMed DOI
B Effects of Berries, Phytochemicals, and Probiotics on Atherosclerosis through Gut Microbiota Modification: A Meta-Analysis of Animal Studies
Meta Analysis International journal of molecular sciences 2023 PubMed DOI
B Berberine Ursodeoxycholate for the Treatment of Type 2 Diabetes: A Randomized Clinical Trial
Rct JAMA network open 2025 PubMed DOI
View all evidence for Berberine →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.