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Calcium 500+D3

product on market Tablet or Pill 21st Century Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 50% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Calcium and vitamin D3 are used to support bone density and mineral absorption. Strong research evidence supports their role in maintaining skeletal health, though overall evidence coverage for this specific formulation is limited. The product maintains a high safety profile.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Calcium 500+D3
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
Single Vitamin and Mineral
Product Type
50%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

5 mcg (25% DV)
Within RDA (0.3× RDA) 608 studies (A:16, B:251)
Calcium
500 mg (38% DV)

Other Ingredients

Maltodextrin Cellulose Contains Less Than 2% of
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: As a calcium supplement, adults take one (1) tablet with any meal, twice daily or as directed by a healthcare provider. Do not exceed recommended dosage.

Warnings & Precautions

Contains shellfish (oyster).

Do not exceed recommended dosage.

Warning: Consult a healthcare provider prior to use if pregnant, nursing, on medications, have a medical condition or are planning a medical procedure.

Stop use and contact a physician if adverse reactions occur.

Keep out of reach of children.

Do not use if product appears to be tampered with or seal is broken.

Formulation Notes

500 mg Calcium 5 mcg (200 IU) Vitamin D3

Contains shellfish (oyster).

Calcium is an important mineral for bone health. Vitamin D3 is added to assist with calcium absorption.

No added Yeast or Artificial Flavors. Gluten Free.

Additional Information

Compare vs. Os-Cal Calcium+D3

Gluten free

Bone Health Support

Individual results may vary.

Store at room temperature.

Guaranteed quality Laboratory tested

Metadata

Product Details

UPC / SKU7 40985 27516 0
DSLD Entry Date2019-10-23
Product TypeSingle Vitamin and Mineral
FormTablet or Pill
Brand21st Century
DSLD ID207511
Data Updated2026-04-11
Research

Research Evidence

849
Research Sources
56
Avg Quality
450
Meta Analysis
152
Rct
137
Systematic Review
73
Clinical Trial
11
Regulatory Source
7
Other
7
Guideline
3
Openfda Safety
2
Cochrane Review
2
Observational
A Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD)
Meta Analysis The Cochrane database of systematic reviews 2018 PubMed DOI
A Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes
Meta Analysis The Cochrane database of systematic reviews 2024 PubMed DOI
A Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life
Meta Analysis The Cochrane database of systematic reviews 2018 PubMed DOI
A Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
A Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps
Systematic Review The Cochrane database of systematic reviews 2008 PubMed DOI
A Calcium and vitamin D for increasing bone mineral density in premenopausal women
Systematic Review The Cochrane database of systematic reviews 2023 PubMed DOI
A Dietary sodium, sodium-to-potassium ratio, and risk of stroke: A systematic review and nonlinear dose-response meta-analysis
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2019 PubMed DOI
A The association between circulating magnesium and clinically relevant outcomes in patients with chronic kidney disease: A systematic review and meta-analysis
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2021 PubMed DOI
A Calcium channel blockers versus other classes of drugs for hypertension
Systematic Review The Cochrane database of systematic reviews 2021 PubMed DOI
View all evidence for Electrolytes →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.