E 450 mg (1000 IU) by 21st Century — Ingredients, Evidence & Safety

Product Label

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Label Data

1 Softgel(s) Serving Size

Vitamin Product Type

100% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin E

450 mg (3000% DV)

📊 30.0× RDA — above typical dose (UL: 1000 mg) 📚 177 studies (Tier A: 3, B: 90)

RDA 15mg This product: 450mg UL 1000mg

Other Ingredients

Gelatin Glycerin refined Soybean Oil purified Water

Label Claims — Verification

❓ Nutrient

❓ All Other

❓ Structure/Function

All Other (98% of products) Structure/Function (81% of products) Nutrient (56% of products) Qualified Health (2% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Directions: As a vitamin supplement, adults take one (1) softgel daily with any meal or as directed by a healthcare provider. Do not exceed recommended dosage.

⚠️ Warnings & Precautions

Do not exceed recommended dosage.

Warning: Consult a healthcare provider prior to use if pregnant, nursing, on medications, have a medical condition or are planning a medical procedure.

Stop use and contact a physician if adverse reactions occur.

Keep out of reach of children.

Do not use if product appears to be tampered with or seal is broken.

Contains soy.

🧪 Formulation Notes

No added Sugar, Salt, Yeast, Preservatives, Artificial Flavors or Colors.

Gluten free

Contains soy.

Vitamin E is an antioxidant nutrient and supports the immune system.

Additional Information

Individual results may vary.

Store at room temperature.

Antioxidant Support

Gluten free

Guaranteed quality Laboratory tested

Product Details

UPC / SKU 7 40985 22324 6

DSLD Entry Date 2019-08-23

Product Type Vitamin

Form Softgel Capsule

Brand 21st Century

DSLD ID 205875

Data Updated 2026-04-11

Research Evidence

253 Research Sources

55 Avg Quality Score

128 Meta Analysis

52 Systematic Review

41 Rct

24 Clinical Trial

3 Regulatory Source

1 Narrative Review

1 Other

1 Guideline

1 Openfda Safety

A Vitamin E supplementation in pregnancy

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI

A Vitamin E for Alzheimer's dementia and mild cognitive impairment

Systematic Review The Cochrane database of systematic reviews 2017

PubMed DOI Cochrane

A Vitamin E for Alzheimer's disease and mild cognitive impairment

Meta Analysis The Cochrane database of systematic reviews 2008

PubMed DOI Cochrane

A Vitamin E for Alzheimer's dementia and mild cognitive impairment

Meta Analysis The Cochrane database of systematic reviews 2012

PubMed DOI Cochrane

A Exercise for intermittent claudication

Meta Analysis The Cochrane database of systematic reviews 2017

PubMed DOI

A Effects of vitamin E supplementation on the risk and progression of AD: a systematic review and meta-analysis

Meta Analysis Nutritional neuroscience 2021

PubMed DOI

A Effect of vitamin E supplementation in rheumatoid arthritis: a systematic review and meta-analysis

Meta Analysis European journal of clinical nutrition 2023

PubMed DOI

A Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)

Rct JAMA 2011

PubMed DOI

A Vitamin E for Alzheimer's dementia and mild cognitive impairment

Meta Analysis The Cochrane database of systematic reviews 2017

PubMed DOI Cochrane

B Vitamin, Mineral, and Multivitamin Supplementation to Prevent Cardiovascular Disease and Cancer: US Preventive Services Task Force Recommendation Statement.

Guideline JAMA 2022

PubMed DOI

View all evidence for Vitamin E →