Black Cohosh by 21st Century — Ingredients, Evidence & Safety

Product Label

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Label Data

1 Vegetarian Capsule(s) Serving Size

Botanical Product Type

0% Evidence Coverage

Supplement Facts — Evidence Check

Black Cohosh

540 mg

📊 Market median: 80.0mg (136 products)

Median 80.0mg This product: 540mg

Other Ingredients

Cellulose Rice Bran Oat Fiber Rice Bran extract Rice hull concentrate

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (79% of products) Nutrient (2% of products) No Claim (1% of products)

Target Groups

Vegetarian Adult Female (18 - 50 Years) Menopause Gluten Free

Product Information

📋 Directions for Use

Directions: As a herbal supplement, adults take one (1) capsule daily with any meal or as directed by a healthcare provider. Do not exceed recommended dosage.

⚠️ Warnings & Precautions

Do not exceed recommended dosage.

Warning: Consult a healthcare provider prior to use if pregnant, nursing, on medications, have a medical condition or are planning a medical procedure.

Stop use and contact a physician if adverse reactions occur.

Keep out of reach of children.

Do not use if product appears to be tampered with or seal is broken.

🧪 Formulation Notes

No added Sugar, Salt, Yeast, Preservatives or Artificial Flavors.

100% Vegetarian.

Women's Health Support

Gluten free

Black Cohosh supports Women's health especially during midlife years.

Additional Information

Individual results may vary.

Store at room temperature.

Improved formula

Gluten free

Guaranteed quality Laboratory tested

Product Details

UPC / SKU 7 40985 21740 5

DSLD Entry Date 2019-08-23

Product Type Botanical

Form Capsule

Brand 21st Century

DSLD ID 205819

Data Updated 2026-04-11

Research Evidence

31 Research Sources

49 Avg Quality Score

23 Systematic Review

5 Meta Analysis

1 Rct

1 Openfda Safety

B [Efficacy of black cohosh extracts for improving low estrogen status induced by postoperative GnRHa treatment in patients with endometriosis: a systematic review]

Systematic Review Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 2020

PubMed

B Black cohosh (Cimicifuga spp.) for menopausal symptoms

Meta Analysis The Cochrane database of systematic reviews 2012

PubMed DOI

B Vasomotor symptoms resulting from natural menopause: a systematic review and network meta-analysis of treatment effects from the National Institute for Health and Care Excellence guideline on menopause

Systematic Review BJOG : an international journal of obstetrics and gynaecology 2017

PubMed DOI

C Suspected black cohosh hepatotoxicity: no evidence by meta-analysis of randomized controlled clinical trials for isopropanolic black cohosh extract

Meta Analysis Menopause (New York, N.Y.) 2011

PubMed DOI

C Review & meta-analysis: isopropanolic black cohosh extract iCR for menopausal symptoms - an update on the evidence

Meta Analysis Climacteric : the journal of the International Menopause Society 2021

PubMed DOI

C Menopausal symptoms

Systematic Review BMJ clinical evidence 2007

PubMed

C Menopausal symptoms