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Grape Seed Extract

product on market Capsule 21st Century Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Grape seed extract contains proanthocyanidins that may support cardiovascular health and provide antioxidant properties. Research evidence for these benefits is generally considered moderate. The ingredient profile maintains a high safety rating for typical users.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Grape Seed Extract
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Vegetarian Capsule(s)
Serving Size
30
Servings
Botanical
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 100.0mg (284 products) 10 studies (A:0, B:4)

Other Ingredients

Rice Bran Oat Fiber Cellulose Contains Less Than 2% of
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: As a herbal supplement, adults take two (2) capsules with any meal, twice daily or as directed by a healthcare provider. Do not exceed recommended dosage.

Warnings & Precautions

Do not exceed recommended dosage.

Warning: Consult a healthcare provider prior to use if pregnant, nursing, on medications, have a medical condition or are planning a medical procedure.

Stop use and contact a physician if adverse reactions occur.

Keep out of reach of children.

Do not use if product appears to be tampered with or seal is broken.

Formulation Notes

No added Sugar, Salt, Yeast, Preservatives, Artificial Flavors or Colors.

100% Vegetarian.

Gluten free

Grape seeds contain a powerful bioflavonoid complex called proanthocyanidins, which have been shown to be a valuable aid in antioxidant support.

Additional Information

Individual results may vary.

Store at room temperature.

Standardized Antioxidant Support

Gluten free

Guaranteed quality Laboratory tested

500387-0916N

Metadata

Product Details

UPC / SKU7 40985 21378 0
DSLD Entry Date2019-08-23
Product TypeBotanical
FormCapsule
Brand21st Century
DSLD ID205624
Data Updated2026-04-11
Research

Research Evidence

14
Research Sources
50
Avg Quality
9
Rct
2
Meta Analysis
2
Clinical Trial
1
Systematic Review
B Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers LDL Cholesterol in Patients with Mild Dyslipidemia: A Multicenter, Randomized Controlled Trial
Rct Nutrients 2023 PubMed DOI
B Efficacy of Bilberry and Grape Seed Extract Supplement Interventions to Improve Glucose and Cholesterol Metabolism and Blood Pressure in Different Populations-A Systematic Review of the Literature
Systematic Review Nutrients 2021 PubMed DOI
B The effect of grape seed extract on cardiovascular risk markers: a meta-analysis of randomized controlled trials
Meta Analysis Journal of the American Dietetic Association 2011 PubMed DOI
B The impact of grape seed extract treatment on blood pressure changes: A meta-analysis of 16 randomized controlled trials
Meta Analysis Medicine 2016 PubMed DOI
B Grape Seed Extract Positively Modulates Blood Pressure and Perceived Stress: A Randomized, Double-Blind, Placebo-Controlled Study in Healthy Volunteers
Rct Nutrients 2021 PubMed DOI
C Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: a randomised, double-blinded, two-arm, parallel, placebo-controlled trial
Rct The British journal of nutrition 2016 PubMed DOI
C Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome
Rct Metabolism: clinical and experimental 2009 PubMed DOI
C Grape seed extract supplementation along with a restricted-calorie diet improves cardiovascular risk factors in obese or overweight adult individuals: A randomized, placebo-controlled trial
Rct Phytotherapy research : PTR 2021 PubMed DOI
C The effect of polyphenol-rich chardonnay seed supplements on peripheral endothelial function.
Rct European journal of nutrition PubMed DOI
C The effects of grape seed extract supplementation on cardiovascular risk factors, liver enzymes and hepatic steatosis in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled study.
Rct BMC complementary medicine and therapies PubMed DOI
View all evidence for Grape Seed →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.