Grape Seed Extract

product on market Capsule 21st Century 🟢 Safety: 100/100
Brand: 21st Century
🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

2 Vegetarian Capsule(s) Serving Size
30 Servings
Botanical Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

100 mg
📊 Market median: 100.0mg (284 products) 📚 10 studies (Tier A: 0, B: 4)
This product: 100mg

Other Ingredients

Rice Bran Oat Fiber Cellulose Contains Less Than 2% of

Label Claims — Verification

❓ All Other
❓ Structure/Function
All Other (99% of products) Structure/Function (85% of products) Nutrient (9% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Directions: As a herbal supplement, adults take two (2) capsules with any meal, twice daily or as directed by a healthcare provider. Do not exceed recommended dosage.

⚠️ Warnings & Precautions

Do not exceed recommended dosage.

Warning: Consult a healthcare provider prior to use if pregnant, nursing, on medications, have a medical condition or are planning a medical procedure.

Stop use and contact a physician if adverse reactions occur.

Keep out of reach of children.

Do not use if product appears to be tampered with or seal is broken.

🧪 Formulation Notes

No added Sugar, Salt, Yeast, Preservatives, Artificial Flavors or Colors.

100% Vegetarian.

Gluten free

Grape seeds contain a powerful bioflavonoid complex called proanthocyanidins, which have been shown to be a valuable aid in antioxidant support.

Additional Information

Individual results may vary.

Store at room temperature.

Standardized Antioxidant Support

Gluten free

Guaranteed quality Laboratory tested

500387-0916N

Product Details

UPC / SKU 7 40985 21378 0
DSLD Entry Date 2019-08-23
Product Type Botanical
Form Capsule
Brand 21st Century
DSLD ID 205624
Data Updated 2026-04-11

Research Evidence

14 Research Sources
50 Avg Quality Score
9 Rct
2 Meta Analysis
2 Clinical Trial
1 Systematic Review
B Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers LDL Cholesterol in Patients with Mild Dyslipidemia: A Multicenter, Randomized Controlled Trial
Rct Nutrients 2023
PubMed DOI
B Efficacy of Bilberry and Grape Seed Extract Supplement Interventions to Improve Glucose and Cholesterol Metabolism and Blood Pressure in Different Populations-A Systematic Review of the Literature
Systematic Review Nutrients 2021
PubMed DOI
B The effect of grape seed extract on cardiovascular risk markers: a meta-analysis of randomized controlled trials
Meta Analysis Journal of the American Dietetic Association 2011
PubMed DOI
B The impact of grape seed extract treatment on blood pressure changes: A meta-analysis of 16 randomized controlled trials
Meta Analysis Medicine 2016
PubMed DOI
B Grape Seed Extract Positively Modulates Blood Pressure and Perceived Stress: A Randomized, Double-Blind, Placebo-Controlled Study in Healthy Volunteers
Rct Nutrients 2021
PubMed DOI
C Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: a randomised, double-blinded, two-arm, parallel, placebo-controlled trial
Rct The British journal of nutrition 2016
PubMed DOI
C Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome
Rct Metabolism: clinical and experimental 2009
PubMed DOI
C Grape seed extract supplementation along with a restricted-calorie diet improves cardiovascular risk factors in obese or overweight adult individuals: A randomized, placebo-controlled trial
Rct Phytotherapy research : PTR 2021
PubMed DOI
C The effect of polyphenol-rich chardonnay seed supplements on peripheral endothelial function.
Rct European journal of nutrition
PubMed DOI
C The effects of grape seed extract supplementation on cardiovascular risk factors, liver enzymes and hepatic steatosis in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled study.
Rct BMC complementary medicine and therapies
PubMed DOI
View all evidence for Grape Seed →

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