🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 67% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

1 Veggie Capsule(s) Serving Size
120 Servings
Other Combinations Product Type
67% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin C
200 mg (220% DV)
15 mg (880% DV)
📊 11.5× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 15mg UL 100mg
📊 Market median: 100.0mg (116 products) 📚 15 studies (Tier A: 0, B: 3)
This product: 100mg

Other Ingredients

Microcrystalline Cellulose Modified Cellulose Silicon Dioxide

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (99% of products) Structure/Function (78% of products) Nutrient (52% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Suggested Adult Use: Take 1 capsule with or without food, or more, as recommended by a nutritionally-informed physician.

⚠️ Warnings & Precautions

Warning: Not to be used when taking MAO inhibitors, selective serotonin reuptake inhibitors (SSRIs), or other anti-depressant medications. It should also not be used by individuals taking any of the category of medications known as “triptans.”

May impair your ability to drive or operate machinery. Should not be taken by individuals sensitive to Vitamin B6.

Keep out of reach of children.

🧪 Formulation Notes

Doctor's Best 5-HTP (5-hydroxy L-tryptophan) contains a naturally occurring metabolite of the amino acid tryptophan. 5-HTP is extracted from the seeds of the Griffonia simplicifolia plant. Vitamin B6 and Vitamin C are important co-factors in the 5-HTP's conversion to serotonin, a neuotransmitter substance found at the junctions (synapses) between neurons. 5-HTP provides support to help maintain mental and emotional well-being and promotes healthy sleep.

Doctor's Best 5-HTP is tested to ensure that it does not contain "Peak X."

Vegan

Non-GMO Gluten Free Soy Free

Additional Information

Helps support mental and emotional well-being Helps promote healthy sleep

YDRB0120-5

Vegan

Store in a cool dry place.

Product Details

UPC / SKU 7 53950 00120 6
DSLD Entry Date 2019-05-28
Product Type Other Combinations
Form Capsule
DSLD ID 202910
Data Updated 2026-04-11

Research Evidence

21 Research Sources
53 Avg Quality Score
11 Systematic Review
6 Rct
4 Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025
View all evidence for 5 Htp →

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