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No-Flush Niacin (Inositol Hexanicotinate) 500 mg

product on market Capsule Solgar Safety: 80/100
80/100

This product is generally safe

  • Niacin: 400mg is 11.4× the Tolerable Upper Intake Level (35mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Inositol hexanicotinate is a form of niacin used to support cholesterol levels without causing the typical flushing response. Research provides moderate evidence for the role of niacin in lipid management, though overall evidence coverage for this specific formulation is limited. The ingredient profile is generally well-tolerated with a high safety score.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 400mg is 11.4× the Tolerable Upper Intake Level (35mg)

Label

Product Label

Label for No-Flush Niacin (Inositol Hexanicotinate) 500 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Vegetable Capsule(s)
Serving Size
Other Combinations
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

400 mg (2500% DV)
Exceeds UL by 11.4× (UL: 35 mg) 196 studies (A:5, B:63)
100 mg
Market median: 550.0mg (217 products) 29 studies (A:0, B:5)

Other Ingredients

Vegetable Cellulose Silica Vegetable Magnesium Stearate
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested use: As a dietary supplement for adults, take one (1) vegetable capsule one to two times daily, preferably with a meal or as directed by a healthcare practitioner.

Warnings & Precautions

Notice: Most people should not experience flushing when using this product. However a few sensitive individuals may experience a temporary skin flushing (hot feeling and skin redness), burning, itching, or rash caused by an increase in blood flow near the skin. Do not take on an empty stomach. Do not take more than the recommended dose unless prescribed by your healthcare practitioner.

Not intended for use by pregnant or nursing women. If you are taking any medications or have any medical condition, consult your healthcare practitioner before use.

Discontinue use and consult your healthcare practitioner if any adverse reactions occur.

Keep out of reach of children.

Do not use if outer bottle seal is missing or damaged.

Formulation Notes

Niacin / Vitamin B3, is a water-soluble vitamin and is part of the B Complex. It is required for the metabolism of carbohydrates and protein into energy. Niacin supports nervous system health. The unique inositol-bound niacin in this formula allows for gentle, no-flush delivery of niacin to the body.

Solgar’s KOF-K certification #K-1250

Gluten, wheat & dairy free

Suitable for vegans

Free of: Gluten, Wheat, Dairy, Soy, Yeast, Sugar, Sodium, Artificial Flavor, Sweetener, Preservatives and Color.

Additional Information

SOLGB71910 02D

Since 1947

Nervous system support Supports energy metabolism

GF Certified Gluten-free K Parve

Store at room temperature.

Metadata

Product Details

UPC / SKU0 33984 01911 9
DSLD Entry Date2019-04-25
Product TypeOther Combinations
FormCapsule
BrandSolgar
DSLD ID201437
Data Updated2026-04-11
Research

Research Evidence

32
Research Sources
50
Avg Quality
19
Rct
7
Meta Analysis
3
Clinical Trial
2
Other
1
Systematic Review
B Greater Choline-Containing Compounds and Myo-inositol in Treatment-Resistant Versus Responsive Schizophrenia: A 1H-Magnetic Resonance Spectroscopy Meta-analysis
Meta Analysis Biological psychiatry. Cognitive neuroscience and neuroimaging 2024 PubMed DOI
B Inositol for Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis to Inform the 2023 Update of the International Evidence-based PCOS Guidelines
Meta Analysis The Journal of clinical endocrinology and metabolism 2024 PubMed DOI
B Antenatal dietary supplementation with myo-inositol for preventing gestational diabetes
Meta Analysis The Cochrane database of systematic reviews 2023 PubMed DOI
B Effectiveness of inositol, metformin and their combination in women with PCOS undergoing assisted reproduction: systematic review and meta-analysis
Meta Analysis Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2022 PubMed DOI
B Effects of myo-inositol vs. metformin on hormonal and metabolic parameters in women with PCOS: a meta-analysis
Meta Analysis Irish journal of medical science 2023 PubMed DOI
B Inositol for subfertile women with polycystic ovary syndrome
Meta Analysis The Cochrane database of systematic reviews 2018 PubMed DOI
B Treatment of lean PCOS teenagers: a follow-up comparison between Myo-Inositol and oral contraceptives
Rct European review for medical and pharmacological sciences 2021 PubMed DOI
B The 40:1 myo-inositol/D-chiro-inositol plasma ratio is able to restore ovulation in PCOS patients: comparison with other ratios
Rct European review for medical and pharmacological sciences 2019 PubMed DOI
C Investigating the effect of combined use of selenium and Myo-inositol supplements on thyroid function and autoimmune characteristics in thyroid disorders: a systematic review and meta-analysis
Meta Analysis Expert review of endocrinology & metabolism 2024 PubMed DOI
C Myo-inositol supplementation to prevent gestational diabetes in overweight non-obese women: bioelectrical impedance analysis, metabolic aspects, obstetric and neonatal outcomes - a randomized and open-label, placebo-controlled clinical trial.
Rct International journal of food sciences and nutrition PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.