Vitamin B-12 500 mcg by Rugby — Ingredients, Evidence & Safety

🟢 100/100

This product looks safe

No ingredients exceed tolerable upper intake levels
100% of ingredients have research evidence

A Label Compliance Grade

Product Label

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Label Data

1 Tablet(s) Serving Size

Vitamin Product Type

100% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin B12

500 mcg (8333% DV)

📊 208.3× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 0.5mg

Other Ingredients

Microcrystalline Cellulose Croscarmellose Sodium Magnesium Stearate Stearic Acid FD&C Yellow #5 Aluminum Lake

Label Claims — Verification

❓ All Other

All Other (99% of products) Structure/Function (89% of products) Nutrient (56% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free Sugar Free

Product Information

📋 Directions for Use

Directions: Adults: As a dietary supplement, take one tablet daily, preferably with a meal, or as directed by a health care professional.

⚠️ Warnings & Precautions

Tamper resistant - Do not use if safety seal is broken or missing.

Warning: If you are pregnant, nursing, taking any medications or planning any medical procedure, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

🧪 Formulation Notes

Free of: Sugar, sodium, starch, wheat, corn, gluten, yeast, soy, egg, fragrance, artificial flavors and preservatives.

Additional Information

New formula and appearance

Keep bottle tightly closed. Store between 15(0)- 30(0)C (59(0)- 86(0)F).

Made in Canada MP 979-05

Rev. 05/17 R-147 Re-order No. 370546

Product Details

UPC / SKU 0 05363 55101 5

DSLD Entry Date 2019-04-25

Product Type Vitamin

Form Tablet or Pill

Brand Rugby

DSLD ID 201265

Data Updated 2026-04-11

Research Evidence

237 Research Sources

53 Avg Quality Score

83 Meta Analysis

74 Systematic Review

45 Rct

29 Clinical Trial

2 Guideline

2 Regulatory Source

1 Openfda Safety

A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis

Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025

PubMed DOI

A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies

Meta Analysis Critical reviews in food science and nutrition 2019

PubMed DOI

A Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency

Systematic Review The Cochrane database of systematic reviews 2018

PubMed DOI Cochrane

A Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression

Meta Analysis Nutrients 2021

PubMed DOI

A Efficacy of different routes of vitamin B12 supplementation for the treatment of patients with vitamin B12 deficiency: A systematic review and network meta-analysis

Systematic Review Irish journal of medical science 2024

PubMed DOI

B Helicobacter pylori infection and micronutrient deficiency in pregnant women: a systematic review and meta-analysis

Meta Analysis BMJ open gastroenterology 2020

PubMed DOI

B Vitamin B12 supplementation during pregnancy for maternal and child health outcomes

Systematic Review The Cochrane database of systematic reviews 2024

PubMed DOI Cochrane

B A comprehensive review and meta-regression analysis of randomized controlled trials examining the impact of vitamin B12 supplementation on homocysteine levels

Meta Analysis Nutrition reviews 2024

PubMed DOI

B Relationship between vitamin B12 levels and motor development: A systematic review

Systematic Review Clinical nutrition ESPEN 2024

PubMed DOI

B Vitamin B12, folate, and homocysteine in metabolic syndrome: a systematic review and meta-analysis

Meta Analysis Frontiers in endocrinology 2023

PubMed DOI

View all evidence for Vitamin B12 →