Vitamin B-12 1000 mcg by Rugby — Ingredients, Evidence & Safety

🟢 100/100

This product looks safe

No ingredients exceed tolerable upper intake levels
100% of ingredients have research evidence

A Label Compliance Grade

Product Label

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Label Data

1 Tablet(s) Serving Size

Vitamin Product Type

100% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin B12

1000 mcg (16666% DV)

📊 416.7× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 1.0mg

Other Ingredients

Microcrystalline Cellulose Croscarmellose Sodium Magnesium Stearate Stearic Acid Silica Carmine

Label Claims — Verification

❓ All Other

All Other (99% of products) Structure/Function (89% of products) Nutrient (56% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

Directions: Adults: As a dietary supplement, take one tablet daily, preferably with a meal, or as directed by a health care professional.

Discontinue use and consult your doctor if any adverse reactions occur.

⚠️ Warnings & Precautions

Tamper resistant - Do not use if safety seal is broken or missing.

Warning: If you are pregnant, nursing, taking any medications or planning any medical procedure, consult your doctor before use.

Keep out of reach of children.

🧪 Formulation Notes

Free of: Sugar, corn, dairy, yeast, soy, egg, gluten, fragrance, gluten, artificial flavors and preservatives.

Additional Information

New formula and appearance

Keep bottle tightly closed. Store between 15(0)- 30(0)C (59(0)- 86(0)F).

Made in Canada MP 978-06

Rev. 05/17 R-147 Re-order No. 370545

Product Details

UPC / SKU 0 05363 55601 0

DSLD Entry Date 2019-04-25

Product Type Vitamin

Form Tablet or Pill

Brand Rugby

DSLD ID 201264

Data Updated 2026-04-11

Research Evidence

237 Research Sources

53 Avg Quality Score

83 Meta Analysis

74 Systematic Review

45 Rct

29 Clinical Trial

2 Guideline

2 Regulatory Source

1 Openfda Safety

A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis

Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025

PubMed DOI

A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies

Meta Analysis Critical reviews in food science and nutrition 2019

PubMed DOI

A Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency

Systematic Review The Cochrane database of systematic reviews 2018

PubMed DOI Cochrane

A Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression

Meta Analysis Nutrients 2021

PubMed DOI

A Efficacy of different routes of vitamin B12 supplementation for the treatment of patients with vitamin B12 deficiency: A systematic review and network meta-analysis

Systematic Review Irish journal of medical science 2024

PubMed DOI

B Helicobacter pylori infection and micronutrient deficiency in pregnant women: a systematic review and meta-analysis

Meta Analysis BMJ open gastroenterology 2020

PubMed DOI

B Vitamin B12 supplementation during pregnancy for maternal and child health outcomes

Systematic Review The Cochrane database of systematic reviews 2024

PubMed DOI Cochrane

B A comprehensive review and meta-regression analysis of randomized controlled trials examining the impact of vitamin B12 supplementation on homocysteine levels

Meta Analysis Nutrition reviews 2024

PubMed DOI

B Relationship between vitamin B12 levels and motor development: A systematic review

Systematic Review Clinical nutrition ESPEN 2024

PubMed DOI

B Vitamin B12, folate, and homocysteine in metabolic syndrome: a systematic review and meta-analysis

Meta Analysis Frontiers in endocrinology 2023

PubMed DOI

View all evidence for Vitamin B12 →