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Vitamin B-12 1000 mcg

product on market Tablet or Pill Rugby Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Vitamin B12 is essential for nerve function and red blood cell formation. There is strong evidence supporting its use in treating deficiencies and supporting metabolic health. This high-dose formulation is generally well-tolerated with a high safety profile.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Vitamin B-12 1000 mcg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

1000 mcg (16666% DV)
416.7× RDA — above typical dose 139 studies (A:1, B:44)

Other Ingredients

Microcrystalline Cellulose Croscarmellose Sodium Magnesium Stearate Stearic Acid Silica Carmine
Claims

Label Claims — Verification

Unverified All Other
Info

Product Information

Directions for Use

Directions: Adults: As a dietary supplement, take one tablet daily, preferably with a meal, or as directed by a health care professional.

Discontinue use and consult your doctor if any adverse reactions occur.

Warnings & Precautions

Tamper resistant - Do not use if safety seal is broken or missing.

Warning: If you are pregnant, nursing, taking any medications or planning any medical procedure, consult your doctor before use.

Keep out of reach of children.

Formulation Notes

Free of: Sugar, corn, dairy, yeast, soy, egg, gluten, fragrance, gluten, artificial flavors and preservatives.

Additional Information

New formula and appearance

Keep bottle tightly closed. Store between 15(0)- 30(0)C (59(0)- 86(0)F).

Made in Canada MP 978-06

Rev. 05/17 R-147 Re-order No. 370545

Metadata

Product Details

UPC / SKU0 05363 55601 0
DSLD Entry Date2019-04-25
Product TypeVitamin
FormTablet or Pill
BrandRugby
DSLD ID201264
Data Updated2026-04-11
Research

Research Evidence

237
Research Sources
53
Avg Quality
83
Meta Analysis
74
Systematic Review
45
Rct
29
Clinical Trial
2
Guideline
2
Regulatory Source
1
Openfda Safety
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
A Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression
Meta Analysis Nutrients 2021 PubMed DOI
A Efficacy of different routes of vitamin B12 supplementation for the treatment of patients with vitamin B12 deficiency: A systematic review and network meta-analysis
Systematic Review Irish journal of medical science 2024 PubMed DOI
B Helicobacter pylori infection and micronutrient deficiency in pregnant women: a systematic review and meta-analysis
Meta Analysis BMJ open gastroenterology 2020 PubMed DOI
B Vitamin B12 supplementation during pregnancy for maternal and child health outcomes
Systematic Review The Cochrane database of systematic reviews 2024 PubMed DOI
B A comprehensive review and meta-regression analysis of randomized controlled trials examining the impact of vitamin B12 supplementation on homocysteine levels
Meta Analysis Nutrition reviews 2024 PubMed DOI
B Relationship between vitamin B12 levels and motor development: A systematic review
Systematic Review Clinical nutrition ESPEN 2024 PubMed DOI
B Vitamin B12, folate, and homocysteine in metabolic syndrome: a systematic review and meta-analysis
Meta Analysis Frontiers in endocrinology 2023 PubMed DOI
View all evidence for Vitamin B12 →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.