Home/ Supplements/ Fenugreek/ SAMe (S-Adenosylmethionine)

SAMe (S-Adenosylmethionine)

product on market Capsule Pure Encapsulations Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

SAMe is used to support mood and joint health, with moderate evidence suggesting efficacy in managing depressive symptoms. Research indicates it may act as a methyl donor in various biochemical reactions. However, overall evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for SAMe (S-Adenosylmethionine)
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
60
Servings
Non-Nutrient/Non-Botanical
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

200 mg
Market median: 200.0mg (52 products) 12 studies (A:0, B:6)

Other Ingredients

Vegetarian Capsule hypoallergenic Plant Fiber Calcium Oxide Ascorbyl Palmitate Calcium Chloride
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Recommendations: As a dietary supplement, take 1 capsule, 1-2 times daily, between meals, or as directed by a health professional.

Warnings & Precautions

Warning: If you are pregnant or lactating, have any health condition or are taking any medication, particularly if you have bipolar disorder or are taking antidepressant medication, consult your health professional before use.

Keep out of the reach of children.

Use only if safety seal is intact.

Formulation Notes

Certified Gluten-Free by the Gluten-Free Certification Organization, www.gluten.org

Gluten-free, Non-GMO & Hypoallergenic

Gluten-free, Non-GMO & Hypoallergenic

Additional Information

Store in a cool, dry place.

Scan to learn about our hypoallergenic supplements

Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity.

Shelf-stable acid-resistant capsules: Supports methylation, positive mood, glutathione production and joint comfort

GF

v5 code: SAM6

Metadata

Product Details

UPC / SKU7 66298 01504 0
DSLD Entry Date2019-01-07
Product TypeNon-Nutrient/Non-Botanical
FormCapsule
DSLD ID185227
Data Updated2026-04-11
Research

Research Evidence

14
Research Sources
50
Avg Quality
8
Rct
4
Meta Analysis
2
Clinical Trial
B The Effect of Fenugreek in Type 2 Diabetes and Prediabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis International journal of molecular sciences 2023 PubMed DOI
B A randomized controlled clinical trial evaluating the effect of Trigonella foenum-graecum (fenugreek) versus glibenclamide in patients with diabetes
Rct African health sciences 2019 PubMed DOI
C The effect of fenugreek seed supplementation on serum irisin levels, blood pressure, and liver and kidney function in patients with type 2 diabetes mellitus: A parallel randomized clinical trial
Rct Complementary therapies in medicine 2020 PubMed DOI
C Effect of saffron and fenugreek on lowering blood glucose: A systematic review with meta-analysis
Meta Analysis Phytotherapy research : PTR 2023 PubMed DOI
C Effect of fenugreek on hyperglycaemia and hyperlipidemia in diabetes and prediabetes: A meta-analysis
Meta Analysis Journal of ethnopharmacology 2016 PubMed DOI
C Effect of fenugreek extract supplement on testosterone levels in male: A meta-analysis of clinical trials
Meta Analysis Phytotherapy research : PTR 2020 PubMed DOI
C Investigating the Effectiveness of Fenugreek on the Quantity of Breast Milk and the Level of Prolactin in Mothers of Preterm Newborns: A Randomized Controlled Clinical Trial
Rct Current drug research reviews 2025 PubMed DOI
C Clinical observation on trigonella foenum-graecum L. total saponins in combination with sulfonylureas in the treatment of type 2 diabetes mellitus
Rct Chinese journal of integrative medicine 2008 PubMed
C Impact of Fenugreek Supplementation on Obesity and Hyperglycemia Among Diabetic Adults in Saudi Arabia
Clinical Trial ClinicalTrials.gov 2025
C Fenugreek bread: a treatment for diabetes mellitus
Rct Journal of medicinal food 2009 PubMed DOI
View all evidence for Fenugreek →
Compare

Similar Products

View all Fenugreek products →

This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.