🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

1 Tablet(s) Serving Size
Vitamin Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

3000 mcg (125000% DV)
📊 1250.0× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 3.0mg

Other Ingredients

Mannitol Croscarmellose Sodium Magnesium Stearate natural source Cherry flavor Farm Fresh Factors

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (99% of products) Structure/Function (89% of products) Nutrient (56% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

Suggested usage: Chew or dissolve 1 tablet per day in the mouth before swallowing or as directed by a health professional.

Natural Factors BioCoenzymated Methylcobalamin & Dibencozide formula is offered in a convenient one-per-day chewable form.

⚠️ Warnings & Precautions

Cautions: As with any supplement, consult your health professional before use if you are pregnant, breastfeeding, or trying to conceive, or if you are taking medication, have a medical condition, or anticipate surgery.

Keep out of the reach of children.

Sealed for your protection. Do not use if seal is broken.

🧪 Formulation Notes

Vitamin B12 helps produce red blood cells, maintain good health, and prevent B12 deficiency states such as pernicious anemia. Methylcobalamin and dibencozide are coenzyme forms of vitamin B12 whereas cyanocobalamin must be converted to its metabolically active coenzyme form in a two-step process. Taking methylcobalamin and/or dibencozide allows for greater absorption and bioavailability than non-coenzyme forms.

Contains no artificial colors, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs.

Suitable for vegetarians/vegans.

B12

Additional Information

isura Non-GMO Mass Spec Documentation Lab Tested

Manufactured by Natural Factors to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.

For freshness, store in a cool, dry place.

Product of Canada Purity & Potency Guaranteed Recyclable container and label.

The most metabolically active form

R0

This product has passed the most rigorous testing in the world for contaminants and quality. isura.com

What does coenzymated mean? In order for B vitamins to be utilized effectively by the body, they must be converted into their metabolically active coenzyme forms. For example, the two coenzyme form of vitamin B12 are methylcobalamin and dibencozide. A coenzyme is a naturally occurring compound that partners with specific enzymes in order to help promote a number of beneficial metabolic reactions in the body. Without the coenzyme, the enzyme cannot promote the biochemical reaction that is responsible for our survival. This dual cooperation between coenzyme and enzyme is a process called coenzymated. Taking B vitamins already in their coenzymated forms allows the body to use them directly. Thus, the amount that is needed by the body is less in order to achieve the same benefits. Biocoenzymated takes it one step further.

The synergy between the phytochemicals found in these plant extracts and the coenzyme B vitamin optimizes absorption. The results? Biocoenzymated delivers the most metabolically active nutrients to your cells to utilize most effectively. Feel the difference.

Product Details

UPC / SKU 0 68958 01253 7
DSLD Entry Date 2018-11-21
Product Type Vitamin
Form Tablet or Pill
DSLD ID 182933
Data Updated 2026-04-11

Research Evidence

237 Research Sources
53 Avg Quality Score
83 Meta Analysis
74 Systematic Review
45 Rct
29 Clinical Trial
2 Guideline
2 Regulatory Source
1 Openfda Safety
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019
A Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency
Systematic Review The Cochrane database of systematic reviews 2018
A Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression
Meta Analysis Nutrients 2021
A Efficacy of different routes of vitamin B12 supplementation for the treatment of patients with vitamin B12 deficiency: A systematic review and network meta-analysis
Systematic Review Irish journal of medical science 2024
B Helicobacter pylori infection and micronutrient deficiency in pregnant women: a systematic review and meta-analysis
Meta Analysis BMJ open gastroenterology 2020
B Vitamin B12 supplementation during pregnancy for maternal and child health outcomes
Systematic Review The Cochrane database of systematic reviews 2024
B A comprehensive review and meta-regression analysis of randomized controlled trials examining the impact of vitamin B12 supplementation on homocysteine levels
Meta Analysis Nutrition reviews 2024
B Relationship between vitamin B12 levels and motor development: A systematic review
Systematic Review Clinical nutrition ESPEN 2024
B Vitamin B12, folate, and homocysteine in metabolic syndrome: a systematic review and meta-analysis
Meta Analysis Frontiers in endocrinology 2023
View all evidence for Vitamin B12 →

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