🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

1 Capsule(s) Serving Size
Amino acid/Protein Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

200 mg
📊 Market median: 100.0mg (116 products) 📚 15 studies (Tier A: 0, B: 3)
This product: 200mg

Other Ingredients

Microcrystalline Cellulose Gelatin Silica Magnesium Stearate

Label Claims — Verification

All Other
Structure/Function
All Other (99% of products) Structure/Function (78% of products) Nutrient (52% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Directions: 1 capsule once daily with a meal, or as directed by your healthcare professional.

⚠️ Warnings & Precautions

Warning: Not for use by children, or women who are pregnant, may become pregnant or breastfeeding.

Warning: Not for use by children, or women who are pregnant, may become pregnant or breastfeeding. If you are taking antidepressants, SSRIs, MAOIs, sedatives, painkillers, or other drugs, or if you have any medical condition, consult your physician before taking 5-HTP.

In some people, temporary nausea, diarrhea, or abdominal discomfort may occur. Discontinue use if any of these symptoms persist for more than three days. May cause drowsiness; do not operate machinery or drive a vehicle until you know how 5-HTP affects you.

Do not use if either tamper-evident seal is broken or missing.

Keep out of the reach of children.

🧪 Formulation Notes

Non GMO

5-HTP (L-5-Hydroxytryptophan) is an intermediate in the natural conversion of the essential amino acid tryptophan to serotonin, a brain chemical associated with positive mood and well-being. Preclinical studies show that 5-HTP may help support healthy levels of serotonin in the body. In addition to a balanced mood, serotonin may also support melatonin production and a healthy sleep cycle. Serene Science 5-HTP is derived from the seeds of the African plant Griffonia simplicifolia.

Additional Information

Balanced mood

Non GMO Validated

Store in a cool, dry place.

SN2663 REV H165

Product Details

UPC / SKU 0 21078 02663 1
DSLD Entry Date 2019-01-07
Product Type Amino acid/Protein
Form Capsule
DSLD ID 181567
Data Updated 2026-04-11

Research Evidence

21 Research Sources
53 Avg Quality Score
11 Systematic Review
6 Rct
4 Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025
View all evidence for 5 Htp →

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