Home/ Supplements/ 5 Htp/ Serene Science 5-HTP 200 mg

Serene Science 5-HTP 200 mg

product on market Capsule Source Naturals Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

5-HTP serves as a precursor to serotonin and is researched for its role in supporting mood and sleep. There is moderate evidence suggesting its efficacy in managing certain mood-related symptoms. This ingredient profile is generally considered safe for most users.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Serene Science 5-HTP 200 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
Amino acid/Protein
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

200 mg
Market median: 100.0mg (116 products) 18 studies (A:0, B:3)

Other Ingredients

Microcrystalline Cellulose Gelatin Silica Magnesium Stearate
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: 1 capsule once daily with a meal, or as directed by your healthcare professional.

Warnings & Precautions

Warning: Not for use by children, or women who are pregnant, may become pregnant or breastfeeding.

Warning: Not for use by children, or women who are pregnant, may become pregnant or breastfeeding. If you are taking antidepressants, SSRIs, MAOIs, sedatives, painkillers, or other drugs, or if you have any medical condition, consult your physician before taking 5-HTP.

In some people, temporary nausea, diarrhea, or abdominal discomfort may occur. Discontinue use if any of these symptoms persist for more than three days. May cause drowsiness; do not operate machinery or drive a vehicle until you know how 5-HTP affects you.

Do not use if either tamper-evident seal is broken or missing.

Keep out of the reach of children.

Formulation Notes

Non GMO

5-HTP (L-5-Hydroxytryptophan) is an intermediate in the natural conversion of the essential amino acid tryptophan to serotonin, a brain chemical associated with positive mood and well-being. Preclinical studies show that 5-HTP may help support healthy levels of serotonin in the body. In addition to a balanced mood, serotonin may also support melatonin production and a healthy sleep cycle. Serene Science 5-HTP is derived from the seeds of the African plant Griffonia simplicifolia.

Additional Information

Balanced mood

Non GMO Validated

Store in a cool, dry place.

SN2662 REV H166

Metadata

Product Details

UPC / SKU0 21078 02662 4
DSLD Entry Date2018-11-21
Product TypeAmino acid/Protein
FormCapsule
DSLD ID181563
Data Updated2026-04-11
Research

Research Evidence

21
Research Sources
53
Avg Quality
11
Systematic Review
6
Rct
4
Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025 PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023 PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025 PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010 PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020 PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025 PubMed DOI
View all evidence for 5 Htp →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.