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Vitamin B12 1000 mcg

product on market Tablet or Pill Nature Made Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 50% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Vitamin B12 is supported by strong evidence for maintaining nerve function and supporting red blood cell formation. Calcium is well-documented for its role in bone health and muscle contraction. However, the overall evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Vitamin B12 1000 mcg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
Single Vitamin and Mineral
Product Type
50%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

1000 mcg (16667% DV)
416.7× RDA — above typical dose 139 studies (A:1, B:44)
Calcium
124 mg (12% DV)

Other Ingredients

Stearic Acid Cellulose Gel Hypromellose Magnesium Stearate Croscarmellose Sodium
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested use: Take one tablet daily with a meal. For easier swallowing, take with water before and during ingestion.

Warnings & Precautions

Store in a cool, dry place, out of reach of children.

Do not use if imprinted seal under cap is broken or missing.

Formulation Notes

No color added No artificial flavors No preservatives No yeast or starch Gluten free

Additional Information

Everyday value #1 pharmacist recommended

List No. 4064 L200 Cat. A495 5A007

Timed release

Supports cellular energy production in the body

Vitamin B12 is important for the metabolic pathways that release cellular energy from fat and protein.

Keep bottle tightly closed. Store in a cool, dry place, out of reach of children.

B12 tablets are made to Nature Made’s guaranteed purity and potency standards. Based on Pharmacy Times Survey of pharmacists recommending Letter Vitamin Supplements.

Metadata

Product Details

UPC / SKU0 31604 04064 2
DSLD Entry Date2018-08-31
Product TypeSingle Vitamin and Mineral
FormTablet or Pill
BrandNature Made
DSLD ID180193
Data Updated2026-04-11
Research

Research Evidence

237
Research Sources
53
Avg Quality
83
Meta Analysis
74
Systematic Review
45
Rct
29
Clinical Trial
2
Guideline
2
Regulatory Source
1
Openfda Safety
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
A Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression
Meta Analysis Nutrients 2021 PubMed DOI
A Efficacy of different routes of vitamin B12 supplementation for the treatment of patients with vitamin B12 deficiency: A systematic review and network meta-analysis
Systematic Review Irish journal of medical science 2024 PubMed DOI
B Helicobacter pylori infection and micronutrient deficiency in pregnant women: a systematic review and meta-analysis
Meta Analysis BMJ open gastroenterology 2020 PubMed DOI
B Vitamin B12 supplementation during pregnancy for maternal and child health outcomes
Systematic Review The Cochrane database of systematic reviews 2024 PubMed DOI
B A comprehensive review and meta-regression analysis of randomized controlled trials examining the impact of vitamin B12 supplementation on homocysteine levels
Meta Analysis Nutrition reviews 2024 PubMed DOI
B Relationship between vitamin B12 levels and motor development: A systematic review
Systematic Review Clinical nutrition ESPEN 2024 PubMed DOI
B Vitamin B12, folate, and homocysteine in metabolic syndrome: a systematic review and meta-analysis
Meta Analysis Frontiers in endocrinology 2023 PubMed DOI
View all evidence for Vitamin B12 →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.