🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

1 Softgel(s) Serving Size
Vitamin Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

5000 mcg (1667% DV)
📊 166.7× RDA — above typical dose 📚 26 studies (Tier A: 0, B: 11)
RDA 0.03mg This product: 5.0mg

Other Ingredients

Soybean Oil Gelatin Glycerin yellow Beeswax Water Soy Lecithin Colors added

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (100% of products) Structure/Function (91% of products) Nutrient (57% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Suggested use: Consult your health care professional before use. Take one softgel daily, with a meal. For easier swallowing, take with water before and during ingestion.

⚠️ Warnings & Precautions

Caution: Do not exceed one softgel daily unless recommended by a health care professional.

Store in a cool, dry place, out of reach of children.

Do not use if imprinted seal under cap is broken or missing.

Contains: Soy.

🧪 Formulation Notes

Maximum Strength Biotin 5000 mcg

Nature Made Maximum Strength Biotin provides 5000 mcg of biotin, a B vitamin that supports carbohydrate, protein and fat metabolism. Biotin may also help support healthy hair, skin and nails for those that are biotin deficient.

Colors derived from natural sources - No synthetic dyes No artificial flavors No preservatives No yeast or starch Gluten free

Contains: Soy.

Additional Information

Everyday value #1 pharmacist recommended

List No. 4063 L200 Cat. A611 5A044

USP Dietary Supplement Verified

Maximum strength for adults diagnosed with very low levels of biotin

Strength levels of Biotin R Regular 300 mcg or below E Extra above 300 mcg up to 2,500 mcg M Maximum above 2,500 mcg up to 5,000 mcg Helps restore healthy levels of biotin in adults with very low levels, as diagnosed by their health care professional using appropriate biomarkers.

Keep bottle tightly closed. Store in a cool, dry place, out of reach of children.

For those with biotin deficiency. USP has tested and verified ingredients, potency, and manufacturing process. USP sets official standards for dietary supplements. www.uspverified.org. Based on Pharmacy Times Survey of pharmacists recommending Letter Vitamin Supplements.

Product Details

UPC / SKU 0 31604 04063 5
DSLD Entry Date 2018-08-31
Product Type Vitamin
Form Softgel Capsule
Brand Nature Made
DSLD ID 180191
Data Updated 2026-04-11

Research Evidence

31 Research Sources
53 Avg Quality Score
12 Meta Analysis
9 Systematic Review
5 Rct
2 Clinical Trial
1 Regulatory Source
1 Openfda Safety
B Pentasaccharides for the treatment of deep vein thrombosis
Meta Analysis The Cochrane database of systematic reviews 2017
B Quantitative comparison of the efficacy of clinical drug treatments for primary progressive multiple sclerosis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2023
B Dietary interventions for multiple sclerosis-related outcomes
Meta Analysis The Cochrane database of systematic reviews 2020
B Interventions for infantile seborrhoeic dermatitis (including cradle cap)
Meta Analysis The Cochrane database of systematic reviews 2019
B Effect of varicocelectomy on sperm deoxyribonucleic acid fragmentation rates in infertile men with clinical varicocele: a systematic review and meta-analysis
Meta Analysis Fertility and sterility 2021
B Effect of feeding biotin on milk production and hoof health in lactating dairy cows: a quantitative assessment
Meta Analysis Journal of dairy science 2011
B Factitious Graves' Disease Due to Biotin Immunoassay Interference-A Case and Review of the Literature
Systematic Review The Journal of clinical endocrinology and metabolism 2016
B Effect of biotin on milk performance of dairy cattle: a meta-analysis
Meta Analysis Journal of dairy science 2011
B PROVIT: Supplementary Probiotic Treatment and Vitamin B7 in Depression-A Randomized Controlled Trial
Rct Nutrients 2020
B High-dose biotin for multiple sclerosis: A systematic review and meta-analyses of randomized controlled trials
Meta Analysis Multiple sclerosis and related disorders 2021
View all evidence for Biotin →

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