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High Potency Magnesium 400 mg

product on market Softgel Capsule Nature Made Safety: 87/100
87/100

This product is generally safe

  • Magnesium: 400mg is 1.1× the Tolerable Upper Intake Level (350mg)
  • 33% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Magnesium is a mineral supported by strong evidence for maintaining healthy nerve and muscle function. Research indicates it plays a critical role in protein synthesis and blood pressure regulation. The evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Magnesium: 400mg is 1.1× the Tolerable Upper Intake Level (350mg)

Label

Product Label

Label for High Potency Magnesium 400 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Softgel(s)
Serving Size
Mineral
Product Type
33%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calories
10 Calorie(s)
Total Fat
0.5 Gram(s) (1% DV)
400 mg (100% DV)
Exceeds UL by 1.1× (UL: 350 mg) 316 studies (A:8, B:159)

Other Ingredients

Medium Chain Triglycerides Gelatin Glycerin Water Soy Lecithin Colors added yellow Beeswax
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

One softgel daily

Suggested use: Take one softgel daily, with a meal. For easier swallowing, take with water before and during ingestion.

Warnings & Precautions

Store in a cool, dry place, out of reach of children.

Do not use if imprinted seal under cap is broken or missing. Caution: Do not exceed one softgel daily or take with other products that contain magnesium, unless recommended by your health care professional.

Product may cause gastrointestinal disturbance, including diarrhea. Consult a physician before use, if you have kidney disease or if you are taking prescription medications.

Contains: Soy.

Formulation Notes

High potency Magnesium 400 mg

Colors derived from natural sources - No synthetic dyes No artificial flavors No preservatives No yeast or starch Gluten free

Contains: Soy.

Additional Information

List No. 2552 L201 Cat. A533 5A009 ITEM # 375283

Helps support nerve, muscle & heart function

Magnesium also helps support healthy bones & teeth and helps convert food into cellular energy

Keep bottle tightly closed. Store in a cool, dry place, out of reach of children.

Magnesium softgels are made to Nature Made’s guaranteed purity and potency standards.

Metadata

Product Details

UPC / SKU0 31604 02552 6
DSLD Entry Date2018-08-31
Product TypeMineral
FormSoftgel Capsule
BrandNature Made
DSLD ID179652
Data Updated2026-04-11
Research

Research Evidence

849
Research Sources
56
Avg Quality
450
Meta Analysis
152
Rct
137
Systematic Review
73
Clinical Trial
11
Regulatory Source
7
Other
7
Guideline
3
Openfda Safety
2
Cochrane Review
2
Observational
A Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD)
Meta Analysis The Cochrane database of systematic reviews 2018 PubMed DOI
A Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes
Meta Analysis The Cochrane database of systematic reviews 2024 PubMed DOI
A Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life
Meta Analysis The Cochrane database of systematic reviews 2018 PubMed DOI
A Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
A Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps
Systematic Review The Cochrane database of systematic reviews 2008 PubMed DOI
A Calcium and vitamin D for increasing bone mineral density in premenopausal women
Systematic Review The Cochrane database of systematic reviews 2023 PubMed DOI
A Dietary sodium, sodium-to-potassium ratio, and risk of stroke: A systematic review and nonlinear dose-response meta-analysis
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2019 PubMed DOI
A The association between circulating magnesium and clinically relevant outcomes in patients with chronic kidney disease: A systematic review and meta-analysis
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2021 PubMed DOI
A Calcium channel blockers versus other classes of drugs for hypertension
Systematic Review The Cochrane database of systematic reviews 2021 PubMed DOI
View all evidence for Electrolytes →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.