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5-HTP 100 mg

product on market Capsule Spring Valley Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 50% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

5-Hydroxytryptophan is used to support mood and sleep, though research evidence for these effects is generally limited. Calcium is a mineral essential for bone health and cellular function with strong scientific backing. This combination provides basic nutritional and mood support.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for 5-HTP 100 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Capsule(s)
Serving Size
15
Servings
Other Combinations
Product Type
50%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calcium
128 mg (10% DV)
Market median: 100.0mg (116 products) 18 studies (A:0, B:3)

Other Ingredients

Dicalcium Phosphate Gelatin Contains <2% of:
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use: Adults, take two capsules daily, preferably at bedtime as 5-HTP may produce drowsiness. If you experience stomach sensitivity, take with food.

Warnings & Precautions

For your protection, do not use if seal under cap is broken or missing.

Warning: Not intended for use by pregnant or nursing women. If you are taking any medications, including antidepressants or drugs with central nervous system or serotonergic activity, or have any medical condition, including mental health or gastrointestinal concerns, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur. Do not drive, operate machinery or consume alcohol when taking this product.

Not intended for use by persons under the age of 18. Keep out of reach of children.

Formulation Notes

L-5-Hydroxytryptophan 100 mg per capsule

No gluten, yeast, wheat, milk or milk derivatives, lactose, sugar, preservatives, soy, artificial color, artificial flavor, sodium (less than 5 mg per serving)

No gluten, yeast, wheat, milk or milk derivatives, lactose, sugar, preservatives, soy, artificial color, artificial flavor, sodium (less than 5 mg per serving)

Additional Information

Please recycle

Item No. 72443 B52335W 03A 108234

Mood health 5-HTP is a precursor to serotonin, a neurotransmitter that supports mood health and well-being.

Product of China

Store at room temperature 59(0)- 86(0)F (15(0)- 30(0)C). Keep bottle tightly closed.

Quality guaranteed

Metadata

Product Details

UPC / SKU6 81131 05853 7
DSLD Entry Date2018-06-25
Product TypeOther Combinations
FormCapsule
DSLD ID178269
Data Updated2026-04-11
Research

Research Evidence

21
Research Sources
53
Avg Quality
11
Systematic Review
6
Rct
4
Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025 PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023 PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025 PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010 PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020 PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025 PubMed DOI
View all evidence for 5 Htp →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.