Home/ Supplements/ 5 Htp/ 5-HTP 100 mg

5-HTP 100 mg

product on market Capsule Bluebonnet Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

5-Hydroxytryptophan is a precursor to serotonin used to support mood and sleep regulation. There is moderate research evidence suggesting its efficacy for managing depressive symptoms, though overall evidence coverage for this specific formulation is limited. The ingredient profile maintains a high safety score.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for 5-HTP 100 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
Amino acid/Protein
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 100.0mg (116 products) 18 studies (A:0, B:3)

Other Ingredients

Kosher Vegetable Capsules Vegetable Cellulose Vegetable Magnesium Stearate
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: As a dietary supplement, take one capsule daily, preferably on an empty stomach at bedtime or as directed by a healthcare practitioner.

Warnings & Precautions

Caution: Consult with your healthcare practitioner prior to use if you are taking prescription medication, particularly cognitive drugs, such as MAO inhibitors and selective serotonin reuptake inhibitors (SSRIs), or other anti-depressant medications.

May cause drowsiness, so refrain from operating machinery or driving a vehicle when taking this product.

Formulation Notes

Bluebonnet’s 5-HTP 100 mg Capsules provide 5-hydroxytryptophan that is extracted from the seed of the African plant Griffonia simplicifolia.

Guaranteed free of Peak-X

Bluebonnet’s KOF-K Certification #K-0000700

Made with non-GMO ingredients

From Griffonia seed extract

Vegan

Free of milk, egg, fish, crustacean shellfish, tree nuts, peanuts, wheat and soybeans. Also free of yeast, gluten, barley, rice, sodium and sugar.

Additional Information

5-HTP is the direct metabolic precursor of serotonin and is important for the production of melatonin; therefore, it has been shown in research to help control appetite, support a positive mood as well as promote calm/relaxation and for occasional sleeplessness. Available in easy-to-swallow vegetable capsules for maximum assimilation and absorption.

0053A

Made with non-GMO ingredients

Vegan

K Parve

Gluten free

Metadata

Product Details

UPC / SKU7 43715 00053 7
DSLD Entry Date2018-04-25
Product TypeAmino acid/Protein
FormCapsule
DSLD ID176487
Data Updated2026-04-11
Research

Research Evidence

21
Research Sources
53
Avg Quality
11
Systematic Review
6
Rct
4
Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025 PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023 PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025 PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010 PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020 PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025 PubMed DOI
View all evidence for 5 Htp →
Compare

Similar Products

View all 5 Htp products →

This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.