Threshold

product on market Powder Optimum Nutrition Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 38% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

The profile contains essential minerals such as magnesium and phosphorus, which support muscle function and energy metabolism. Research provides strong evidence for the roles of these minerals in maintaining systemic health. However, overall evidence coverage for this specific formulation is very limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Threshold
Open Full PDF View on NIH DSLD →
Details

Label Data

2.7 Gram(s)
Serving Size
75
Servings
Other Combinations
Product Type
38%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calories
Total Carbohydrates
15 mg (4% DV)
Market median: 500.0mg (1 products) 316 studies (A:8, B:159)
70 mg (7% DV)
Within RDA (0.1× RDA) 13 studies (A:0, B:3)
Sodium
20 mg (1% DV)
Potassium
55 mg (2% DV)
1.6 g
Market median: 1500.0mg (104 products) 21 studies (A:0, B:2)
L-Histidine
550 mg

Other Ingredients

Silicon Dioxide
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

DIRECTIONS: Add 1 scoop of Threshold(TM) to a glass or shaker cup filled with 6-8 oz. of cold water or your favorite beverage. Mix or shake thoroughly for 15-20 seconds or until powder is completely dissolved. SUGGESTED USE: Consume one serving first thing in the morning and a second serving approximately 30 minutes before your workout (or mid-afternoon on non-training days).

Warnings & Precautions

KEEP OUT OF REACH OF CHILDREN.

CHECK WITH A QUALIFIED HEALTH CARE PROFESSIONAL BEFORE TAKING THIS PRODUCT IF YOU ARE PREGNANT OR NURSING A BABY, UNDER 18 YEARS OF AGE, HAVE ANY KNOWN OR SUSPECTED MEDICAL CONDITIONS, AND/OR IF YOU ARE TAKING ANY PRESCRIPTION OR OTC MEDICATIONS.

Formulation Notes

1.6G BETA ALANINE

Packed with Beta-Alanine, Histidine, and Phosphates our Threshold(TM) formula is designed to help boost your intramuscular buffering system so that you can train harder, longer.†

Additional Information

75 SERVINGS (3 arrows) 1,600 MG MUSCLE FATIGUE FIGHTER†

07-234-094

CarnoSyn(R) Carnosine Synthesizer

Nutritional uses of ß-alanine are licensed from Natural Alternatives International, Inc. under US Patents #5,965,596; 6,172,098 and 6,680,294.

THE BIGGER PICTURE OF MUSCLE STAMINA During high-intensity training, glucose and glycogen are broken down for energy. In the process, hydrogen ions (H+) are also produced within the muscles. H+ accumulation causes the muscles to become more acidic and ultimately leads to fatigue.

ON(TM)

(2 arrows) UNFLAVORED

STORE TIGHTLY-CLOSED CONTAINER IN A COOL, DRY PLACE.

Metadata

Product Details

DSLD Entry Date2013-02-25
Product TypeOther Combinations
FormPowder
DSLD ID17572
Data Updated2026-04-11
Research

Research Evidence

849
Research Sources
56
Avg Quality
450
Meta Analysis
152
Rct
137
Systematic Review
73
Clinical Trial
11
Regulatory Source
7
Other
7
Guideline
3
Openfda Safety
2
Cochrane Review
2
Observational
A Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD)
Meta Analysis The Cochrane database of systematic reviews 2018 PubMed DOI
A Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes
Meta Analysis The Cochrane database of systematic reviews 2024 PubMed DOI
A Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life
Meta Analysis The Cochrane database of systematic reviews 2018 PubMed DOI
A Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
A Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps
Systematic Review The Cochrane database of systematic reviews 2008 PubMed DOI
A Calcium and vitamin D for increasing bone mineral density in premenopausal women
Systematic Review The Cochrane database of systematic reviews 2023 PubMed DOI
A Dietary sodium, sodium-to-potassium ratio, and risk of stroke: A systematic review and nonlinear dose-response meta-analysis
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2019 PubMed DOI
A The association between circulating magnesium and clinically relevant outcomes in patients with chronic kidney disease: A systematic review and meta-analysis
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2021 PubMed DOI
A Calcium channel blockers versus other classes of drugs for hypertension
Systematic Review The Cochrane database of systematic reviews 2021 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.